Serviços Personalizados
Journal
Artigo
Indicadores
- Citado por SciELO
- Acessos
Links relacionados
- Similares em SciELO
Compartilhar
Jornal Português de Gastrenterologia
versão impressa ISSN 0872-8178
Resumo
MURINELLO, António; TOME, Teresa; GOULAO, Augusto e COHEN, Álvaro. Zinc therapy of neurological Wilsons disease in a woman with two foetus with agenesis of the corpus callosum. J Port Gastrenterol. [online]. 2010, vol.17, n.3, pp.116-125. ISSN 0872-8178.
CLINICAL REPORT: A patient diagnosed Wilsons disease (WD) 22 years previously, successfully treated initially with zinc, developed neuropsychiatric disease after years of irregular therapy. Reassuming zinc therapy was successful. After a normal pregnancy, she had two therapeutic abortions for corpus callosum agenesis, and a missed abortion. We review the genetics, physiopathology, clinics and imagiologic response to zinc therapy, the problems of pregnancy in WD, advising to maintain therapy. A hypothetic cause for fetus brain anomaly would be hypocupremia due to zinc therapy, confronting with two other possibilities, one related to Wilsons disease in itself, other due to a congenital syndrome of agenesis of the corpus callosum, impossible to diagnose by our available diagnostic methods.
Palavras-chave : Wilsons disease; zinc; corpus callosum agenesis; hypocupremia.