Abstract

JORGE, João Xavier et al. Relationship between colonic transit and age, gender, disease duration, and HbA1c in type 2 diabetes mellitus. J Port Gastrenterol. [online]. 2013, vol.20, n.2, pp.52-57. ISSN 0872-8178.  https://doi.org/10.1016/j.jpg.2012.12.006.

Introduction: In diabetes, the digestive transit may be altered. Nevertheless, the influence of some factors is controversial. The aim of this study is to examine the influence of age, gender, disease duration and HbA1c on the colonic transit of diabetic patients. Population and methods: Thirty eight type 2 diabetic patients, aged between 44 and 81, were enrolled. Two abdominal radiographs were conducted, 24 and 72 hours after the ingestion of 25 radiopaque particles. We examined the relationship between the number of particles in the right and left colon, sigmoid colon - rectum and total colon and age, gender, disease duration and glycosylated hemoglobin (HbA1c). t statistics were performed, and the results are in mean ± SD. Results: At 24 hours, the number of particles in the colon was significantly higher in patients with HbA1c ≤ 7%/l vs. > 7%, 18.6 ± 6.3 vs. 13.1 ± 8.5 p < 0.004, and, at 72 hours, the age (≤ 60 years vs. > 60 years), gender and HbA1c did not influence significantly the number of particles in the colon. In patients with disease duration ≤ 10 years vs> 10 years, the number of particles in the right and left colon were: 0.49±1.17 vs. 0.18±0.46, p > 0.05, 1.46±3.7 vs. 3.97±6.4, p < 0.05, respectively. In the sigmoid colon and rectum were: 1.26±3.39 vs. 2.2±2.5, p < 0.01, and total 3.20±6.0 vs. 7.55±8.8, p < 0.02. Conclusions: 1 - At 24 hours, patients with HbA1c ≤ 7% had significantly more particles in the colon. 2 - At 72hours, the patients with ≤ 10 years of disease had significantly less radiopaque particles in the colon. 3 - The age, gender, and the HbA1c did not have any effects, at 72 h.

Keywords : Colonic transit; Radiopaque particles; Type 2 diabetes mellitus.

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