Abstract

RODRIGUES, João Vicente Linhares et al. GASTROINTESTINAL TRANSIT OF Rattus norvegicus (Berkenhout, 1769) (Rodentia:Muridae) AFTER TEGASEROD ADMINISTRATION. J Port Gastrenterol. [online]. 2014, vol.21, n.4, pp.138-146. ISSN 0872-8178.  https://doi.org/10.1016/j.jpg.2014.02.005.

In a study conducted at the physiology laboratory of the Federal University of Juiz de Fora (UFJF), forty wistar rats were divided into two groups, one receiving saline, and the other gavage-administered tegaserod, 1.0 ml/animal, for 15 days. Thirty-four animals, seventeen in each group, reached the end of the experiment. Tegaserod dose was 0.09 mg/kg. The study aimed to assess the effects of tegaserod on the speed of gastrointestinal transit of wistar rats. Scintigraphic reading of the dissected digestive tracts (from the lower esophagus to the rectum) being used to assess intestinal transit. The scintigraphic assessment of the distance covered by the radiotracer in the dissected digestive tract of all animals did not show any statistically significant difference (p = 0.1). We conclude that tegaserod, in the 0.09 mg/kg dose, did not accelerate the intestinal transit of Wistar rats.

Keywords : Intestinal transit; Tegaserod; Rats.

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