Abstract

LUNARDI, Cláudia Cruz et al. Association study between FTO gene variations and body composition in older Brazilian women. Motri. [online]. 2015, vol.11, n.4, pp.26-35. ISSN 1646-107X.  https://doi.org/10.6063/motricidade.3514.

GenomeWide Association Studies (GWAS) suggest an important contribution of gene FTO in body composition and muscle strength in different populations and wide age. This study intended to examine the association of polymorphisms in the FTO gene (rs9939609 and rs1861868) with obesity phenotypes in a sample of Brazilian elderly women not Caucasian. The sample included 241 older women. Data concerning body composition were measured by dual energy X-ray absorptiometry (DXA) and genotyping of SNPs was carried out using the system snapshot Multiplex System (Applied Biosystems). There was no statistically significant difference for body composition variables, even after adjustment for African ancestry. Specifically, body mass index (p= 0.94 and p= 0.66), fat percentage (p= 0.42 and p= 0.93) and total fat free mass (p= 0.75 and p= 0.30) did not present significant differences between genotypes (p values related to rs9939609 and rs1861868, respectively). In this sample of Brazilian elderly, the studied FTO gene polymorphisms (rs9939609 and rs1861868) are not associated with obesity-related phenotypes.

Keywords : gene; obesity; elderly; women; densitometry; BMI; gene FTO.

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