Abstract

MORAIS, Jéssica Brenda Rodrigues Medeiros; SOL, Izabella; RODRIGUES, Cristóvão Marcondes de Castro  and  MACEDO, Dhiancarlo Rocha. The importance of multiprofessional care in the treatment of Stevens-Johnson syndrome associated with the use of Afatinib Dimaleate: a case report by a Hospital Dentistry Team. Rev Port Estomatol Med Dent Cir Maxilofac [online]. 2021, vol.62, n.3, pp.181-185.  Epub Sep 30, 2021. ISSN 1646-2890.  https://doi.org/10.24873/j.rpemd.2021.08.843.

Stevens-Johnson syndrome is an uncommon delayed hypersensitivity reaction primarily associated with drug use, manifested primarily through rashes, ulcerations of the mucous membranes lining the mouth, genitals, and eyes. Afatinib dimaleate is a tyrosine kinase inhibitor that targets the epidermal growth factor receptor and is indicated as a monotherapy for the treatment of non-small-cell lung carcinoma. The Stevens-Johnson syndrome is a rare adverse effect of that medication. The present report aims to present a unique case of Stevens-Johnson syndrome in a young male patient after afatinib dimaleate treatment for pulmonary adenocarcinoma, emphasizing the dental therapeutic perspective concerning this condition’s oral manifestations.

Keywords : Afatinib; Oral mucositis; Lung neoplasms; Stevens-Johnson syndrome.

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