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Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial
Print version ISSN 1646-2890On-line version ISSN 1647-6700
Abstract
SOUZA JUNIOR, Erasmo Freitas de et al. Preemptive analgesia in third molar surgery: A randomized clinical trial comparing two multimodal associations. Rev Port Estomatol Med Dent Cir Maxilofac [online]. 2022, vol.63, n.1, pp.12-19. Epub Mar 30, 2022. ISSN 1646-2890. https://doi.org/10.24873/j.rpemd.2022.01.861.
Objective:
This study aimed to verify the effect of preemptive administration of dexamethasone 8 mg co-administered with paracetamol 1 g compared with dexamethasone 8 mg co-administered with nimesulide 100 mg in surgeries for extracting third molars.
Methods:
A prospective, randomized, triple-blind clinical trial was conducted, allocating patients into two groups by the split-mouth method: Group 1 received dexamethasone and paracetamol, and Group 2 received dexamethasone and nimesulide. Each patient underwent two surgeries on different occasions, evaluating the parameters: pain, number of consumed rescue analgesics, time to the first rescue analgesic consumption, edema, trismus, and patient satisfaction.
Results:
Similar results were found in pain, trismus, number of rescue analgesics ingested, time until ingesting the first rescue analgesic, and overall assessment variables. However, Group 1 showed better results regarding edema, with a statistically significant difference in the 48-h period (p=0.028).
Conclusion:
Dexamethasone 8 mg plus paracetamol 1 g is effective for preemptive analgesia.
Keywords : Anti-inflammatory agents; Edema; Pain; Third molar; Trismus.
