Abstract

CARVALHO, Maria João et al. Estetrol clinical efficacy and safety: therapeutic evidence of a novel estrogen. Acta Obstet Ginecol Port [online]. 2021, vol.15, n.2, pp.161-169.  Epub June 30, 2021. ISSN 1646-5830.

Estetrol (E4) is a native fetal estrogen with a distinct pharmacological profile, acting preferentially on alpha estrogen receptors. Estetrol (15 mg) in combination with drospirenone (3 mg) has been recently approved for contraception. The advantage of hormonal combined contraception with estetrol is demonstrated by neutral impact on hemostatic factors, decreased modulation on lipidic parameters which creates a unique safety profile that emphasizes the utility of E4 in clinical practice. Besides, the E4 use for the treatment of menopause related symptoms and for breast and prostate cancer control has been extensively studied.

Keywords : Estetrol; Oral contraceptive; Menopause; Breast cancer.

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