Abstract

SILVA, Ana Filipa; CASTRO, Andreia Cunha; FIGUEIREDO, Carlos José  and  SANTOS, Emília dos. Postmenopausal hormone replacement therapy and risk of breast and gynecologic cancer. Acta Obstet Ginecol Port [online]. 2023, vol.17, n.2, pp.135-150.  Epub June 30, 2023. ISSN 1646-5830.

Hormone Therapy (HT) is the most effective treatment for symptom control during menopause due to hypoestrogenism. Studies that linked HT to the risk of breast cancer led to a decrease in its prescription. This article seeks to review the risk of breast and gynecologic cancer associated with HT use. It is concluded that it’s a safe and effective option in symptomatic menopausal woman up to the age of 60, without contraindications, in the first 10 years post-menopause. The main concern prescribing it is the risk of breast cancer, which is only significant with a prolonged use over 5 years.

Keywords : Hormone replacement therapy; Postmenopausal; Genital neoplasms, female; Breast neoplasms; Endometrial neoplasms; Cervical uterine neoplasms; Ovarian neoplasms.

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