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Revista da Sociedade Portuguesa de Dermatologia e Venereologia
Print version ISSN 2182-2395On-line version ISSN 2182-2409
Abstract
ROCHA, Kelvin Oliveira; ZANUNCIO, Virgínia Vinha; VALADARES, Flávia Diniz and LIMA, Luciana Moreira. COVID-19 and Cutaneous Disorders: What’s Being Reported? A Meta-Analysis from Observational Studies and Case Reports. Rev Soc Port Dermatol Venereol [online]. 2020, vol.78, n.4, pp.25-33. Epub Sep 10, 2021. ISSN 2182-2395. https://doi.org/10.29021/spdv.78.4.1290.
Background:
Coronavirus disease (COVID-19) is related to several extrapulmonary disorders; however, little is known about the skin disorders characteristics and prevalence.
Objetive:
Summarize and evaluate the skin disorders’ characteristics and prevalence reported in the literature. Methods: We conducted a search on PubMed, SciELO and ScienceDirect between 01/01/2020 to 09/28/2020. The target population was patients with skin disorder and a positive diagnosis for COVID-19. All observational studies, research letters, case series and case reports were selected. We evaluated observational studies using Random-effects models to calculate the weighted mean prevalence and 95% confidence interval (CI). We evaluated the case studies using the chi-square test for dichotomous variables and the Mann-Whitney test for continuous variables.
Results:
Eighty-seven patients from case reports and six observational studies with 363 patients were selected. Eleven types of skin disorders in COVID-19 confirmed patients are described. Skin disorder weighted mean prevalence was 9.9% (95% CI: 3.7-24.1). Maculopapular rash was the most prevalent disorder (37.5%; 95% CI: 21-57%). Latency was significantly lower in patients over 60 years old (p=0.041).
Conclusion:
Each cutaneous manifestation has its particularities and may or may not accompany other signs and symptoms. It is possible for the elderly to have COVID-19- related skin disorders early.
Keywords : Coronavirus Infections; COVID-19; Skin Diseases; Skin Manifestations.