Abstract

PEREIRA, Vanessa; RODRIGUES, Carina  and  CORTEZ, Filipa. Genetic, epigenomic, metagenomic and cronobiological factors of obesity. Acta Port Nutr [online]. 2019, n.17, pp.22-26. ISSN 2183-5985.  https://doi.org/10.21011/apn.2019.1704.

Obesity is a multifactorial disease, which results from a combination of both genetic (polygenic) and environmental factors. Obesity is a well-established risk factor for type II diabetes Mellitus, cardiovascular disease, respiratory disease, and certain types of cancer. Technological development that has been observed in recent decades has allowed us to greatly expand our knowledge about molecular and cellular mechanisms associated to its pathophysiology. Among the "new sciences" that have emerged, nutritional genomics is a new area of study that reveals the role of individual genetic background and gene-nutrient interaction in obesity development. This article intends to present a review of the new approaches in the study of obesity and to discuss the importance of this knowledge in the prevention and treatment of the disease. The knowledge of interindividuality variability in the genetic, epigenomic, metagenomic and chronobiological pattern of obesity will allow the development of better tools for diagnosis and treatment of obesity.

Keywords : Chronobiology; Nutritional genomics; Metagenomics; Nutrition, Obesity.

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