Abstract

QUEIROS, Ana Sofia et al. GLUCOSAMINE: EVIDENCE IN THE TREATMENT OF OSTEOARTHRITIS. Acta Port Nutr [online]. 2022, n.28, pp.60-63.  Epub July 16, 2022. ISSN 2183-5985.  https://doi.org/10.21011/apn.2022.2811.

Osteoarthritis is a chronic multifactorial degenerative disease of the articular cartilage, characterized by joint pain and loss of function. Glucosamine consists of an amino-monosaccharide and an essential component of articular cartilage. It is produced endogenously, but it can also be administered as a slow-acting drug in osteoarthritis to reduce symptoms.

This literature review aims to understand the effects of glucosamine on osteoarthritis, specifically its metabolism, mechanism of action, efficacy, and safety.

A literature search was carried out, based on articles published in the last ten years, in “Pubmed” and “Sciencedirect” databases, using the descriptors “glucosamine” in association with “osteoarthritis” and “pharmacokinetics”. Official recommendations from health organizations were also considered.

Orally administered glucosamine is absorbed in the duodenum and transported by GLUT-2 into cells. This compound participates in the hexosamine pathway, contributing to the biosynthesis of proteoglycans and glycoproteins, which are significant components of the extracellular matrix of the cartilage. In osteoarthritis, glucosamine has an anti-inflammatory and protective effect against cartilage degradation.

According to the literature, the therapeutic dose of glucosamine capable of decreasing joint pain and improving function is 1500 mg/ day. The brand and formulation are essential factors for its effectiveness. This substance was considered safe, and no serious adverse effects or cases of overdose were observed.

Glucosamine may have a positive effect on alleviating the symptoms of osteoarthritis. However, there is still no consensus on its efficacy, nutrient-drug interactions and impacts on glucose metabolism. Therefore, further studies are needed.

Keywords : Joint pain; Glucosamine; Slow-acting drug; Osteoarthritis; Food supplement.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf )