Introduction

The SARS-CoV-2 pandemic has brought new and challenging problems to health care systems. More than ever, the screening and identification of disease transmission chains has proved to be extremely complex and important.

The accurate diagnosis remains as a fundamental pillar of the screening, which is currently based on the molecular detection of SARS-CoV-2 in respiratory samples. This strategy may be insufficient for an effective control of the pandemic since the diagnostic performance of the molecular detection varies over time after exposure and is dependent on the sensitivity and specificity of the tests used.

Case Report

A case report of a healthcare professional with a clinical and epidemiological context (chronologically and geographically) highly suggestive of COVID-19 who, repeatedly, had a negative result in the molecular search for the disease agent. The maintenance of complaints and imperiousness to control secondary cases, motivated the more detailed study using serological tests of specific immunoglobulins for SARS-CoV-2 that proved to be reactive.

Discussion/Conclusion

The primary role of clinical suspicion in a pandemic scenario is highlighted and the need for careful interpretation of complementary diagnostic tests in the light of the evolution of scientific evidence. The intervention of the Occupational Health Service is also emphasized, both in terms of diagnosis and in monitoring the case in order to promote the health of the professional and to protect the remaining members of the healthcare staff and patients.

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