Introduction/framework/objectives:

Latex allergy is recognized as a widespread health problem that assumed serious proportions in the 1990s. Although preventive measures have markedly decreased its incidence, recent studies have shown that it remains an important health problem in certain population groups, particularly in developing countries. This work aims to provide a comprehensive review of the current status of occupational latex allergies. We summarize various aspects of this condition, such as prevalence, risk groups, latex allergens, the diagnostic approach, prevention, and treatment.

Methodology:

A bibliographic review was carried out in January 2023 in the following databases: PubMed/Medline, Cochrane Library, Evidence-based Medicine, Canadian Medical Association, Practice Guidelines and National Guideline Clearinghouse.

Content:

Repeated exposure to latex in an occupational context can lead to worker sensitivity, with a significant clinical and socio-economic impact. We summarize various aspects of this condition, such as prevalence, risk groups, latex allergens, the diagnostic approach, prevention and treatment.

Discussion and Conclusions:

The history of latex allergies has demonstrated that potent allergens such as Natural Rubber Latex proteins can cause rapid immunoglobulin-E-mediated sensitization and clinical allergies, reaching serious proportions in highly exposed individuals. Occupational exposure has a decisive influence on the allergen sensitivity profile, with important clinical and therapeutic consequences. The effectiveness of secondary prevention measures is limited. Thus, it is essential to implement early primary prevention measures in individuals belonging to risk groups, to avoid or minimize exposure to latex allergens.

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