Resumo

ROSETE, Marisa et al. Acute Cholestatic Hepatitis Caused by Amoxicilin/Clavunate. Gaz Med [online]. 2020, vol.7, n.4, pp.392-395.  Epub 22-Jul-2021. ISSN 2183-8135.  https://doi.org/10.29315/gm.v7i4.378.

A 65-year-old man was admitted to the emergency room, with a history of abdominal pain, choluria, fecal acholia, generalized pruritus and anorexia for four days. He indicated that it had been approximately 21 days since he had used amoxicillin/calvulanate for 7 days for tonsillitis and denied using any other medications. Laboratory data showed direct hyperbilirubinemia and elevated liver enzymes. Diagnostic investigation began with serological tests for virus, bacteria and auto-immunity which were negative. A liver biopsy was performed, and the pathology showed hepatocellular inflammation, cholestasis, and bile duct damage.

Conclusion: The patient was diagnosed with cholestatic hepatitis associated with amoxicillin/clavulanate. He did not receive any specific treatment, only cholestyramine and ursodeoxycholic acid for pruritus.

Palavras-chave : Amoxicillin-Potassium Clavulanate Combination/adverse effects; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic/etiology.

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