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Gazeta Médica
versão impressa ISSN 2183-8135versão On-line ISSN 2184-0628
Resumo
BRAGA, Madalena et al. Reed's Syndrome: A Rare Systemic Genodermatosis. Gaz Med [online]. 2023, vol.10, n.3, pp.225-228. Epub 30-Set-2023. ISSN 2183-8135. https://doi.org/10.29315/gm.v1i1.624.
Reed's syndrome is an autosomal dominant rare genodermatosis, characterized by the presence of multiple cutaneous and uterine leiomyomatosis. This syndrome can be associated with renal cell carcinoma and leiomyosarcoma.
A 55-year-old woman presented to routine consultation. Physical examination was notorious for the presence of multiple asymmetrical, irregular, skin-colored, with a smooth surface papules and nodules on her chest and left arm. They had been present for about two decades. The patient's past medical history was significant for myomectomy and hysterectomy. A cutaneous papule’s biopsy revealed a leiomyoma. Clinical and histological findings combined with surgical history suggested Reed's syndrome, which was later confirmed by genetic tests. Her family was referred for genetic counseling.
Systematic review of skin lesions is essential, as they can be the diagnostic clue for systemic diseases.
Palavras-chave : Kidney Neoplasms; Leiomyomatosis; Neoplastic Syndromes, Hereditary; Skin Neoplasms.