Abstract

JESUS, Josiane Borges Ferreira de. Does muscle mass play a role in inflammatory markers and iron metabolism in hemodialytic patients?. PsychTech [online]. 2022, vol.5, n.2, pp.42-46.  Epub Mar 07, 2022. ISSN 2184-1004.  https://doi.org/10.26580/pthj.art40-2022.

The present study investigated the impact of sarcopenia traits on the anthropometric profile, pro-and anti-inflammatory cytokines, factors related to iron metabolism, and the risk of mortality in hemodialysis patients. The sample consisted of 247 participants; 177 were included in the sample aged 66.8 (± 3.34) years. End-stage renal disease (glomerular filtration rate <15 mL/min/1.73m2) with arteriovenous fistula distributed into three groups: Low Muscle Mass, Dynapenia, and Sarcopenia. All patients had hypertension and diabetes. Among 247 subjects, 38 (15.4%) died during the study. Of that number of deaths, 9.3% were non-sarcopenic, and 32.3% were sarcopenic (p < .0001). Based on Cox proportional hazard analysis, participants in the sarcopenic group had a higher risk of death (HR: 2.492; 95% CI: 1.165 - 5.5331) (p < .0001). The findings showed that muscle mass plays an important protective role for poor prognosis in patients with CKD, as the anthropometric, inflammatory, and iron metabolism profiles tend to be compromised in the face of low strength and low muscle mass.

Keywords : sarcopenia; chronic kidney disease; hemodialysis.

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