Abstract

SOUSA, Arthur Wagner Pimentel de et al. Polyglandular Syndrome Type III and Severe Peripheral Neuropathy: An Unusual Association. GE Port J Gastroenterol [online]. 2015, vol.22, n.1, pp.15-18. ISSN 2341-4545.  https://doi.org/10.1016/j.jpge.2014.08.001.

Introduction: Polyglandular syndrome is characterized by the association of autoimmune, organ-specific, endocrine and non-endocrine diseases. Objective: To present a case of polyglandular syndrome type III (b) accompanied by pernicious anemia and autoimmune thyroiditis. Method: Report the clinical case of a young patient that developed progressive and disabling peripheral neuropathy framework, triggered by vitamin B12 deficiency. Discussion: It was proven that atrophic gastritis with positive intrinsic anti-factor was responsible for the framework of pernicious anemia, which in turn dangerously reduced the sérum levels of vitamin B12, leading to myelopathy. There was a progressive neurological improvement after parenteral cyanocobalamin replacement, keeping the patient at ambulatory, under maintenance therapy. Conclusion: The importance of suspecting on polyglandular syndrome in the presence of autoimmune frameworks is important, especially those involving diabetes, thyroiditis, atrophic gastritis, pernicious anemia, vitiligo, among others.

Keywords : Gastritis; Atrophic; Anemia; Pernicious; Thyroiditis; Autoimmune; Vitamin B 12 Deficiency; Spinal Cord Diseases.

        · abstract in Portuguese     · text in English     · English ( pdf )