Abstract

PINTO, Cláudia et al. Diagnosis of MALT Lymphoma from Surveillance Endoscopy of a Patient with a CDH1 Gene Germline Mutation. GE Port J Gastroenterol [online]. 2022, vol.29, n.1, pp.51-55.  Epub July 19, 2022. ISSN 2341-4545.  https://doi.org/10.1159/000514652.

Carriers of the mutated CDH1 gene have an increased risk of developing early-onset signet-ring cell (diffuse) gastric cancer. We present a case of a young patient with a confirmed mutation of the CDH1 gene, who was diagnosed with a gastric marginal zone B-cell lymphoma (MZL) of mucosa-associated lymphoid tissue (MALT lymphoma) from surveillance endoscopy. He underwent Helicobacter pylori eradication treatment and was subsequently submitted to a total prophylactic gastrectomy. The surgical specimen only revealed foci of signet-ring cell carcinoma (SRCC) in situ without lymphoma signs. We highlight here the occurrence of other pathology in high-risk patients as well as its possible influence on the decision to perform gastrectomy.

Keywords : CDH1 protein; Stomach neoplasms; Helicobacter pylori; Marginal zone B-cell lymphoma.

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