Background/Aims:

Endoscopic submucosal dissection (ESD) has been proposed for removal of gastrointestinal sub-epithelial tumors (GI-SETs), but data are still scanty. This study aimed to report a case series from a western country.

Patients and Methods:

Data of patients with upper GI-SETs suitable for ESD removal observed in 4 centers were retro-spectively reviewed. Before endoscopic procedure, the lesion was characterized by endosonographic evaluation, histology, and CT scan. The en bloc resection and the R0 resection rates were calculated, as well as incidence of complications, and the 1-year follow-up was reported.

Results:

Data of 84 patients with esophageal (N = 13), gastric (N = 61), and duodenal (N = 10) GI-SETs were collected. The mean diameter of lesions was 26 mm (range: 12-110 mm). There were 17 gastrointestinal stromal tumors, 12 neuroendocrine tumors, 35 leiomyomas, 18 lipomas, and 2 hamartomas. En bloc and R0 resection were achieved in 83 (98.8%) and in 80 (95.2%) patients, respectively. Overall, a complication occurred in 11 (13.1%) patients, including bleeding (N = 7) and perforation (N = 4). Endoscopic approach was successful in all bleedings, but 1 patient who required radiological embolization, and in 2 perforations, while surgery was performed in the other patients. Overall, a surgical approach was eventually needed in 5 (5.9%), including 3 in whom R0 resection failed and 2 with perforation.

Conclusions:

Our study found that ESD may be an effective and safe alternative to surgical intervention for both benign and localized malignant GI-SETs.

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