SciELO - Scientific Electronic Library Online

 
vol.31 número1O crescente panorama do carcinoma hepatocelular associado ao fígado gordo não alcoólico e o seu impacto no rastreioDisseção endoscópica da submucosa em resseções maiores que 10 cm: outcomes de um centro português índice de autoresíndice de assuntosPesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

  • Não possue artigos similaresSimilares em SciELO

Compartilhar


GE-Portuguese Journal of Gastroenterology

versão impressa ISSN 2341-4545

Resumo

BANAKH, Iouri et al. Ultrarapid Iron Polymaltose Infusions Are Safe for Management of Iron Deficiency. GE Port J Gastroenterol [online]. 2024, vol.31, n.1, pp.24-32.  Epub 01-Mar-2024. ISSN 2341-4545.  https://doi.org/10.1159/000527794.

Introduction:

Iron deficiency is a common condition, especially among patients with kidney and heart failure and inflammatory bowel disease. Intravenous iron is the preferred method of treatment in these patients, but it usually requires prolonged iron polymaltose infusions or multiple administrations of alternative preparations. The aim of the study was to confirm the safety and patient acceptance of ultrarapid iron polymaltose infusions as an alternative to slower treatments and ferric carboxymaltose.

Method:

An open-label, phase 4 safety study was conducted at a tertiary hospital, with consenting participants diagnosed with iron deficiency and requiring iron polymaltose up to 1,500 mg receiving the infusion over 15 min. The acute adverse event (AE) rates and their severities were compared to historical controls of 1- and 4-h iron polymaltose infusions from a retrospective study of 648 patients from the same study site. Delayed AEs as well as participant infusion acceptability were also studied.

Results:

Three hundred participants over a 2-year period received ultrarapid infusions of iron polymaltose with an acute AE rate of 18.7% and severe AE rate of 1.0%. The total and mild infusion AE rates were higher compared to those of slower infusions (p < 0.001), but comparable for moderate and severe AEs. Delayed reactions occurred in 12.5% of participants, with over 95% of them preferring repeat ultrarapid infusions if required again.

Conclusion:

Iron polymaltose can be safely infused at ultrarapid rates when compared to slower infusions, with similar safety to ferric carboxymaltose, of-fering greater convenience for patients and reduced health-care costs.

Palavras-chave : Iron deficiency; Iron infusion; Safety; Treatment and hospital.

        · resumo em Português     · texto em Inglês     · Inglês ( pdf )