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Portuguese Journal of Dermatology and Venereology
Print version ISSN 2795-501XOn-line version ISSN 2795-5001
Abstract
SOARES-CARDOSO, Sandra et al. Stevens-Johnson syndrome/toxic epidermal necrolysis overlap triggered by ethosuximide: a rare pediatric report. Port J Dermatol Venereol. [online]. 2023, vol.81, n.2, pp.124-128. Epub Feb 27, 2023. ISSN 2795-501X. https://doi.org/10.24875/pjdv.22000041.
Introduction:
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe and life-threatening mucocutaneous conditions characterized by fever and necrosis of the epidermis. Up to 90% of cases are drug-induced. Antiseizure drugs (ASD) are known to cause SJS, but only a very few ethosuximide-induced SJS cases have been reported in the literature.
Case presentation:
We report a case of ethosuximide-induced SJS/TEN overlap in a 4-year-old boy, confirmed by patch tests, with improvement with intravenous immunoglobulin (IVIG) and systemic corticosteroid therapy cycle.
Conclusion:
This case highlights the need to expand knowledge about the optimal treatment strategy for these rare conditions, in addition to supportive treatment.
Keywords : Antiepileptic drug; Ethosuximide; Stevens-Johnson syndrome; Toxic epidermal necrolysis.
