Trombocitopenia e Sarcoidose

Apresentação de Um Caso Clínico e Revisão da Literatura

 

Anabela Silva; Ana Costa; Estela Ramos

 

Serviço de Medicina Interna, Hospital Pedro Hispano, Matosinhos

 

Os autores apresentam um caso de trombocitopenia grave de causa presumivelmente imune numa jovem do sexo feminino que tinha sido previamente medicada com griseofulvina para tratamento de lesões cutâneas. O estudo revelou apresentar uma Sarcoidose estadio II. Discutem ainda a relação etiopatogénica entre ambas as doenças e as implicações terapêuticas.

Palavras-chave: Sarcoidose; Trombocitopenia; Griseofulvina

 

Trombocytopenia and Sarcoidosis

The authors present a case of severe most probably immune-mediated thrombocytopenia in a young female that had been medicated with griseofulvin for cutaneous lesions, whose diagnosis was stage II Sarcoidosis. They also discuss the etiopathogenic relationship between both conditions, as well as the therapeutic implications.

Key-words: Sarcoidosis; Thrombocytopenia; Griseofulvin.

 

Texto completo disponível apenas em PDF.

Full text only available in PDF format.

 

REFERÊNCIAS

1- Newman LS, Rose CS, Maier LA: Sarcoidosis. N Engl J Med 1997; 336:1224-34.        [ Links ]

2 - Joint Statement of the American Thoracic Society, the European Respiratory Society and the World Association of Sarcoidosis and Other Granulomatous Disorders adopted by the ATS Board of Directors and the ERS Executives Committee, February, 1999: Statement on Sarcoidosis. Am J Respir and Critical Care Med 1999;160:736-55.

3 - Mayock RL, Bertrand P, Morrison CE, et al: Manifestations of sarcoidosis. Am J Med 1963;35:67-89.

4 - Lawrence HJ, Greenberg BR: Autoimmune thrombocytopenia in Sarcoidosis. Am J Med. 1985;79:761-4.

5 - Dickerman JD, Holbrook FR, Zinkham WH: Etiology and therapy of thrombocytopenia associated with sarcoidosis. J Pedriatr 1972;81:758-64.

6 - Knodel AR, Beekman JF. Severe thrombocytopenia and sarcoidosis. JAMA 1980;243:258-9.

7 - Chakrabarti S, Behera D, Varma S, et al: High-dose methylprednisolone for autoimmune thrombocytopenia in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 1997;14:188.

8 - Viallard JF, Parrens M, Hermine O, et al: Severe prolonged red blood cell aplasia and thrombocytopenia induced by parvovirus B19 infection in a patient with sarcoidosis. Clin Infect Dis 2003;36:229-33.

9 - Scharma OP: Sarcoidosis and other autoimmune disorders. Curr Opin Pulm Med 2002;8:542-6

 

Correspondência:

Dr.ª Anabela Silva

Serviço de Medicina

Hospital Pedro Hispano

Rua Dr. Eduardo Torres

4450 Matosinhos

e-mail: anabeladoc@yahoo.com