Determination of Azithromycin in Pharmaceutical Formulations by Differential Pulse Voltammetry. Comparison with Fourier Transformed Infrared Spectroscopic Analysis

 

J. Araujo, R. Ortíz,* W. Velásquez, J.M. Ortega

 

Universidad de Los Andes, Facultad de Ciencias, Departamento de Química,

Laboratorio de Electroquímica, Mérida 5101, Venezuela

 

 

Received 7 March 2005; accepted in revised form 28 September 2005

 

 

Abstract

Differential Pulse Voltammetry (DPV) and Fourier Transformed Infrared Spectroscopy (FTIRS) techniques have been applied and compared, for the azithromycin determination in two different pharmaceutical formulations (capsules and suspension). Both methods were found to be highly precise with high recovery levels (more than 98 %) The analytical results obtained with the electrochemical method showed excellent correlation with the analytical results obtained by FTIRS. The proposed electrochemical methodology presents the advantage over FTIRS of being able to be used directly on azithromycin samples in capsules presentation as well as in suspension, since no interferences were observed from the excipients of the formulation, nevertheless the direct analysis of the suspension was not possible by FTIRS due to excipients interference.

Keywords: azithromycin, antibiotic analysis, DPV analysis, electrochemical determination, FTIRS analysis.

 

 

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* Corresponding author. E-mail address: reynaldo@ula.ve