Polarographic Analysis of Quetiapine in Pharmaceuticals

 

Nahed El-Enany,* Amina El-Brashy, Fathalla Belal, Nihal El-Bahay

 

Faculty of Pharmacy, Department of Pharmaceutical Analytical Chemistry, University of Mansoura, Mansoura, 35516, Egypt

 

Received 18 September 2008; accepted 11 February 2009

 

Abstract

The voltammetric behaviour of quetiapine (QTP) was studied using direct current (DC_t), differential pulse (DPP) and alternating current (AC_t) polarography. The drug manifests cathodic waves over the pH range of 6 – 11.8. The waves were characterized as being irreversible, diffusion-controlled with limited adsorption properties. At pH 8, the diffusion current-concentration relationship was rectilinear over the range of 8 – 44 μg/mL and 4 – 44 μg/mL using DC_t and DPP modes, respectively, with minimum detection limits (LOD) of 0.06 μg/mL and  0.04 μg/mL using the DC_t and DPP modes, respectively. The diffusion-current constant (I_d) is 1.36 ± 0.04  (n = 10). The proposed method was successfully applied to the determination of the studied compound both in pure form and in formulations. The results obtained were favourably compared with those obtained using a reference method. A pathway for the electrode reaction was postulated.

Keywords: quetiapine, dosage form, polarography.

 

 

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*Corresponding author. E-mail address: nelenany1@yahoo.com