Differential diagnosis between glomus tumor and carcinoid of the stomach

D. A. Athanazio, M. P. Motta, A. Motta, E. Studart , P. R. F. Athanazio

 

Departamento de Biointeração, Universidade Federal da Baía, Salvador, Brasil

Escola Bahiana de Medicina e Saúde Pública, Salvador, Brasil

Hospital Espanhol, Salvador, Brasil

Hospital Português, Salvador, Brasil

Departamento de Anatomia Patológica, Universidade Federal da Baía, Salvador, Brasil

 

RESUMO

Apresentamos um caso raro de tumor glômico gástrico com diagnóstico pré-operatório de tumor carcinóide num paciente masculino de 57 anos. O painel imunofenotípico revelou expressão de actina de músculo liso e vimentina nas células tumorais, marcação pericelular do colágeno tipo IV e ausência de expressão de marcadores neuroendócrinos. Recentes avanços no diagnóstico e compreensão do comportamento do tumor glômico gástrico são revistos. O presente caso enfatiza a intersecção de achados entre tumor glômico e carcinóide gástricos, o que sugere que a imuno-histoquímica deve ser sempre aplicada para este diagnóstico diferencial.

Palavras-chave: Tumor glômico; Tumor carcinóide; Estômago

 

 

SUMMARY

We report a rare case of gastric glomus tumor with preoperative diagnosis of carcinoid tumor in a 57-year-old man. Immunophenotyping panel revealed expression of smooth muscle actin and vimentin by tumor cells with pericellular collagen IV and absence of expression of neuroendocrine makers. Recent advances on diagnosis of gastric glomus tumor and understanding of its biological behaviour is reviewed. This case highlights the overlapping features of gastric glomus tumor and carcinoid suggesting that immunohistochemistry should be considered for this differential diagnosis in all cases.

Keywords: Glomus tumor; Carcinoid tumor; Stomach.

 

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Correspondência:

Daniel Abensur Athanazio

Departamento de Biointeração – ICS – UFBA

Av. Reitor Miguel Calmon s/no – Campus do Canela.

40.110-100 Salvador – Bahia – Brasil

Tel: +55 71 3245 8602.

E-mail: daa@ufba.br

 

Recebido para publicação: 04/01/2008

Aceite para publicação: 09/04/2008