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Acta Obstétrica e Ginecológica Portuguesa

versão impressa ISSN 1646-5830

Acta Obstet Ginecol Port vol.17 no.3 Algés set. 2023  Epub 30-Set-2023

 

Case Report/Caso Clínico

Fetal goiter: prenatal diagnosis and management

Bócio fetal: diagnóstico e orientação pré natal

Vanessa Vieira1 
http://orcid.org/0000-0002-8662-8442

Mariana Sucena1 

Filipa Sousa1 

Filipa Nunes1 

Miguel Branco1 

1. Centro Hospitalar e Universitário de Coimbra. Portugal.


Abstract

Clinical hyperthyroidism complicate 0.2 to 0.7% of pregnancies, mostly caused by Graves’ disease. A 26-years-old, pregnant woman, was referred to a tertiary center due to Graves’ disease. At 32-weeks, it was identified an enlargement of fetal thyroid gland. Cordocentesis confirmed fetal hypothyroidism. Maternal antithyroid drugs were suspended and intramniotic levothyroxine was administered, improving the thyroid function. The pregnancy ended at 37 weeks, with spontaneous vaginal delivery. Umbilical cord blood sample showed normal thyroid function. Fetal hypothyroidism should be thoroughly evaluated, diagnosed and treated, as it is a treatable cause of delayed psychomotor development.

Keywords: Fetal goiter; Fetal hypothyroidism; Cordocentesis

Resumo

O hipertiroidismo clínico complica 0,2 a 0,7% das gestações, na maioria por doença de Graves. Grávida de 26 anos, com doença de Graves. Às 32 semanas, foi identificado bócio fetal e confirmado hipotiroidismo após realização de cordocentese. Foram suspensos os fármacos antitiroideus maternos e administrada levotiroxina intramniótica, resultando na diminuição da glândula tiroideia e na melhoria da sua função. A gravidez terminou em parto vaginal espontâneo às 37 semanas, confirmando-se a normalização da função tiroideia fetal no sangue do cordão umbilical. O hipotiroidismo fetal deve ser diagnosticado e tratado precocemente, dado ser causa potencialmente tratável de atraso do desenvolvimento psicomotor.

Palavras-chave: Bócio fetal; Hipotiroidismo fetal; Cordocentese

Introduction

Clinical hyperthyroidism occurs in 0.2-0.7% of pregnancies, and Graves’ disease (GD) is responsible for about 95% of these cases1,2.

Due to both thyrotropin receptor antibodies (TRAb) and antithyroid drugs (ATDs) crossing the placenta, treatment of Graves’ disease can be a challenge3. It is necessary to balance control of maternal hyperthyroidism while maintaining a euthyroid state in the fetus3. In some cases, the maternal overtreatment with ATDs may be responsible for fetal hypothyroidism, which can be suspected by the enlargement of the fetal thyroid gland on prenatal ultrasound2,4.

The authors describe a case of prenatal diagnosis and management of fetal goiter related to maternal Graves’ disease.

An informed consent was obtained from the patient before writing this manuscript.

Case report

A 26-years-old caucasian pregnant woman, G2P1 (previous gestation without complications) was referred to a tertiary center due to Graves’ disease, at 12 weeks gestation. The patient was diagnosed after her first pregnancy and was treated with methimazole since then. At 12 weeks, her thyroid function was not satisfactorily controlled. TRAb level was 24 U/L (normal range: < 1U/L), so the treatment with a higher dose of methimazole was necessary. At 25 weeks, due to a normalization of her thyroid function, the necessary dose of methimazole was lower.

Fetal ultrasound scans at 12, 21 and 29 weeks of gestation were normal. The 32 week ultrasound identified an enlargement of fetal thyroid gland, both diameter and circumference superior to the 95th percentile (Figure 1), and hyperextension of the fetal neck Figure 2). No other findings were seen, to help the differential diagnosis between fetal hypo or hyperthyroidism. As the fetal thyroid enlargement persisted, cordocentesis was performed at the 34 weeks to determine fetal thyroid status, which revealed fetal hypothyroidism [thyroid stimulating hormone (TSH) was 75 uUI/mL (normal range: 0,4 to 4 uUI/mL) and free thyroxine (FT4) was 0,62 ng/dL (normal range: 0,7 to 1,5 ng/dL)]. Maternal therapy with methimazole was suspended and 0,4 mg of levothyroxine was administered into the amniotic fluid. After one week, fetal thyroid presented a decreasing of its biometry (28% in thyroid circumference), and fetal thyroid function improved (TSH of 0,53 uUI/mL). Fetal therapy was performed with weekly intra-amniotic injections of 0,4 mg of levothyroxine until 36 weeks, and amniotic fluid levels of TSH and FT4 were obtained each time.

Figure 1 Fetal goiter: ultrasound transverse view of the fetal neck at 32 weeks, showing an anterior solid homogeneous bilobed mass, that is symmetric around the trachea. 

Figure 2 Fetal goiter: ultrasound sagital view of the fetal neck at 32 weeks, showing an enlargement of the thyroid causing hyperextension of the neck. 

At 37 weeks and 4 days, the patient was admitted in spontaneous labor, resulting in vaginal delivery. The male newborn weighted 2385 gr and the Apgar score was 8/8/10. Umbilical cord blood sample showed: TSH of 10 UI/mL (normal range: 0.70 to 15.20 UI/mL), FT4 of 0,75 ng/dL (normal range: 1.05 to 3.21 ng/dL) and TRAb of 13 U/L (normal range: < 0.1 U/L). He was discharged at day 4. On day 15 after delivery, the newborn had normal thyroid function and the TRAb level was 9.9 IU/L. At 1 year-old, the infant has normal growth and no evidence of psychomotor development delay.

Discussion

Maternal Graves’ disease is the most common cause of fetal goiter and, if not properly managed, can result in severe maternal, fetal, and neonatal morbidity and mortality5.

Fetal goiter is defined as an abnormal enlargement of the fetal thyroid gland circumference or diameter above the 95th percentile) 6. It is found in about 19% of the fetuses carried by mothers with GD, and it indicates thyroid dysfunction6. However, fetal goiter can be present not only in cases of fetal hyperthyroidism, but also in fetal hypothyroidism3,6. Other ultrasound findings that can be present in cases of fetal hyperthyroidism are fetal tachycardia, growth restriction and nonimmune fetal hydrops3,4. In extreme cases, hearth failure can cause fetal death3.

Ultrasound combined with color Doppler is helpful for the initial diagnosis and monitoring, but has limited ability to discriminate between fetal hyperthyroidism and hypothyroidism5. Cordocentesis is the gold standard method for confirming fetal thyroid hormone levels for a fetal thyroid diagnosis6.

This case showed that, the balance between the risk of fetal hypothyroidism due to ATD placental passage and fetal hyperthyroidism due to TRAB placental passage, can be difficult to manage in Graves’ disease.

Fetal hypothyroidism should be thoroughly evaluated, diagnosed and treated, as it is a treatable cause of delayed psychomotor development. Fetal therapy can be done not only by administering drugs to the mother, but also by injecting levothyroxine into the amniotic fluid, which does not cross the placenta4,6.

Authors’ contribution

VV, MS: Literature review, draft of the manuscript. FS: Draft of the manuscript. FN, MB: Critical review of the manuscript. All authors were closely involved in the follow up of the patient.

Conflicts of interest

All authors report no conflict of interest.

Patient consent

Obtained.

References

1. ACOG . Thyroid Disease in Pregnancy: ACOG Practice Bulletin, Number 223. Obstet Gynecol. 2020 Jun;1356):e261-e274. doi: https://doi.org/10.1097/AOG.0000000000003893. [ Links ]

2. Cuff RD. Hyperthyroidism During Pregnancy A Clinical Approach. Clin Obstet Gynecol. 2019 Jun;622)320-329. Doi: https://doi.org/10.1097GRF.0000000000000435. [ Links ]

3. Kobaly K, Mandel SJ. Hyperthyroidism and Pregnancy. Endocrinol Metab Clin North Am. 2019 Sep;483)533-545. Doi: https://doi.org/10.1016j.ecl.2019.05.002. [ Links ]

4. Polak M, Luton D. Fetal thyroidology. Best Pract Res Clin Endocrinol Metab. 2014 Mar;282):161-73. doi: https://doi.org/10.1016/j.beem.2013.04.013.. [ Links ]

5. Iijima S. Current knowledge about the in utero and peripartum management of fetal goiter associated with maternal Graves' disease. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2019;3:100027. [ Links ]

6. Kim MJ, Chae YH, Park SY, Kim MY. Intra-amniotic thyroxine to treat fetal goiter. Obstet Gynecol Sci. 2016;591):66-70. doi: https://doi.org/10.5468/ogs.2016.59.1.66. [ Links ]

Received: March 18, 2023; Accepted: June 06, 2023

Correspondence to Vanessa Vieira E-mail: vanessasofia-94@hotmail.com

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