<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2183-5985</journal-id>
<journal-title><![CDATA[Acta Portuguesa de Nutrição]]></journal-title>
<abbrev-journal-title><![CDATA[Acta Port Nutr]]></abbrev-journal-title>
<issn>2183-5985</issn>
<publisher>
<publisher-name><![CDATA[Associação Portuguesa de Nutrição]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2183-59852024000300042</article-id>
<article-id pub-id-type="doi">10.21011/apn.2024.3808</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[STRESS OXIDATIVO E INFERTILIDADE: UMA REVISÃO NARRATIVA]]></article-title>
<article-title xml:lang="en"><![CDATA[OXIDATIVE STRESS AND INFERTILITY: A REVIEW]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guimarães]]></surname>
<given-names><![CDATA[Marcela Rodrigues Moreira]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Oliveira]]></surname>
<given-names><![CDATA[Marie de]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[Ana Rita]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Clínica Ergo, Reprodución, Ginecología y Obstetrica  ]]></institution>
<addr-line><![CDATA[Gijón ]]></addr-line>
<country>Espanha</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Nutrition Academy  ]]></institution>
<addr-line><![CDATA[Queluz de Baixo ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Universitário Egas Moniz Centro de Investigação Interdisciplinar Egas Moniz (CiiEM) ]]></institution>
<addr-line><![CDATA[Caparica ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2024</year>
</pub-date>
<numero>38</numero>
<fpage>42</fpage>
<lpage>46</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2183-59852024000300042&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2183-59852024000300042&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2183-59852024000300042&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO A infertilidade é uma doença do sistema reprodutivo masculino e/ou feminino definida pela incapacidade de atingir uma gravidez após 12 meses ou mais de relações sexuais regulares desprotegidas. A etiopatogénese pode estar associada ao estilo de vida moderno ou a alterações metabólicas, que se observam frequentemente com o aumento da idade materna, obesidade, diabetes, ansiedade, consumo de álcool, tabaco e exposição aos poluentes ambientais, incluindo os que atuam como desreguladores endócrinos. Um fator comum a estas condições é a produção excessiva de espécies reativas de oxigénio que podem dar origem ao stress oxidativo. Assim, o objetivo da presente revisão de literatura é estudar a existência de uma associação entre o stress oxidativo e a incidência de infertilidade. A pesquisa foi realizada na base de dados Pubmed, entre fevereiro e abril de 2023. Utilizou-se como palavras chave: ¨oxidative stress¨, ¨fertility¨. ¨infertility¨, ¨female infertility¨ e ¨male infertility¨. No que diz respeito ao sistema reprodutor, o stress oxidativo pode afetar a qualidade dos gâmetas, oócitos, espermatozoides, embriões e os ambientes respetivos. Adicionalmente, afeta o desenvolvimento embrionário precoce e a implantação, o que por sua vez pode comprometer a taxa de gravidez. Por fim, tem ainda sido associado negativamente à estimulação ovariana, e consequentemente ao potencial desenvolvimento de oócitos na fertilização in vitro. Neste sentido, a partir da presente revisão, torna-se possível afirmar que o stress oxidativo desempenha um papel importante na infertilidade feminina e masculina, constituindo implicações claras para a prevenção, diagnóstico e resolução terapêutica de tais condições.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Infertility is a male and/or female reproductive system disease, defined by the inability to achieve pregnancy after more than 12 months of regular unprotected intercourse. The etiology may be associated with modern lifestyle or metabolic changes, such as increasing maternal age, obesity, diabetes, anxiety, alcohol consumption, smoking and exposure to environmental pollutants, including those that act as endocrine disruptors. A common factor in these conditions is the overproduction of reactive oxygen species that may lead to oxidative stress. Thus, the aim of the present literature review is to study whether there is an association between oxidative stress and the incidence of infertility. A literature search was carried in Pubmed database between February and April 2023. Were used the key words: ¨oxidative stress¨, ¨fertility¨. ¨infertility¨, ¨female infertility¨ and ¨male infertility¨. Regarding to the reproductive system, oxidative stress can affect the quality of gametes, oocytes, sperm, embryos and their environments. Additionally, it affects early embryonic development and implantation, which in turn affects pregnancy rate. Moreover, it has been negatively associated to ovarian stimulation, thus, on potential oocyte development in in vitro fertilization. Therefore, from the present review work it is possible to state that oxidative stress plays an important role in female and male infertility, constituting clear implications for the prevention, diagnosis and therapeutic resolution of such conditions.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Fertilidade]]></kwd>
<kwd lng="pt"><![CDATA[Infertilidade]]></kwd>
<kwd lng="pt"><![CDATA[Infertilidade Feminina]]></kwd>
<kwd lng="pt"><![CDATA[Infertilidade Masculina]]></kwd>
<kwd lng="pt"><![CDATA[Stress oxidativo]]></kwd>
<kwd lng="en"><![CDATA[Fertility]]></kwd>
<kwd lng="en"><![CDATA[Infertility]]></kwd>
<kwd lng="en"><![CDATA[Female Infertility]]></kwd>
<kwd lng="en"><![CDATA[Male Infertility]]></kwd>
<kwd lng="en"><![CDATA[Oxidative Stress]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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