<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0872-671X</journal-id>
<journal-title><![CDATA[Medicina Interna]]></journal-title>
<abbrev-journal-title><![CDATA[Medicina Interna]]></abbrev-journal-title>
<issn>0872-671X</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0872-671X2023000200034</article-id>
<article-id pub-id-type="doi">10.24950/rspmi.1087</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Late Clearance of Chronic Hepatitis C: A Rare Case Report]]></article-title>
<article-title xml:lang="pt"><![CDATA[Eliminação Tardia de Hepatite C Crónica: A Propósito de um Caso Clínico]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Soares]]></surname>
<given-names><![CDATA[Leonor Coutinho]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Matos]]></surname>
<given-names><![CDATA[André Rebelo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vieira]]></surname>
<given-names><![CDATA[Marta Mello]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cruz]]></surname>
<given-names><![CDATA[Rita]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moreira]]></surname>
<given-names><![CDATA[Laura]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Azevedo]]></surname>
<given-names><![CDATA[Luísa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital de São José Centro Hospitalar Universitário de Lisboa Central Serviço de Medicina 1]]></institution>
<addr-line><![CDATA[Lisboa ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital de São José Centro Hospitalar Universitário de Lisboa Central Unidade de Urgência Médica]]></institution>
<addr-line><![CDATA[Lisboa ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Centro Hospitalar de Setúbal Hospital de São Bernardo Serviço de Urgência]]></institution>
<addr-line><![CDATA[Setúbal ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2023</year>
</pub-date>
<volume>30</volume>
<numero>2</numero>
<fpage>34</fpage>
<lpage>36</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0872-671X2023000200034&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0872-671X2023000200034&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0872-671X2023000200034&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Hepatitis C virus (HCV) infection is one of the leading causes of chronic liver disease worldwide. The long-term impact of HCV infection is highly variable, from minimal changes to extensive fibrosis and cirrhosis, with or without progression to hepatocellular carcinoma. Spontaneous viral clearance of HCV, defined by sustained undetectable serum viral load concentrations, occurs in about 20%-25% of those infected, usually within the first 6 to 12 months after primary infection. We present the case of a patient admitted to an internal medicine ward with a likely chronic HCV infection, without epidemiological context, but with established liver disease and cirrhosis, who developed a process of spontaneous elimination, due to acute Epstein Barr virus infection.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo A infeção pelo vírus da hepatite C (HCV) é uma das principais causas de doença hepática crónica em todo o mundo. As consequências da infeção a longo prazo são altamente variáveis, desde alterações hepáticas ligeiras até fibrose e cirrose, com possível progressão para carcinoma hepatocelular. A eliminação espontânea do HCV é definida como persistência carga viral indetetável de forma sustentada e acontece em 20%-25% dos infetados, geralmente nos primeiros 6 a 12 meses pós infeção. Os autores apresentam um caso de uma doente internada numa enfermaria de medicina interna com uma provável infeção crónica por HCV, não previamente conhecida e sem contexto epidemiológico, a condicionar doença hepática com cirrose, que desenvolveu um processo de eliminação espontânea no contexto de infeção vírica aguda.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Anticorpos Neutralizantes]]></kwd>
<kwd lng="pt"><![CDATA[Hepatite C Crónica]]></kwd>
<kwd lng="pt"><![CDATA[Hepatite C.]]></kwd>
<kwd lng="en"><![CDATA[Antibodies, Neutralizing]]></kwd>
<kwd lng="en"><![CDATA[Hepatitis C]]></kwd>
<kwd lng="en"><![CDATA[Hepatitis C, Chronic.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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