<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2795-5001</journal-id>
<journal-title><![CDATA[Portuguese Journal of Dermatology and Venereology]]></journal-title>
<abbrev-journal-title><![CDATA[Port J Dermatol Venereol.]]></abbrev-journal-title>
<issn>2795-5001</issn>
<publisher>
<publisher-name><![CDATA[Permanyer Publications]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2795-50012022000200138</article-id>
<article-id pub-id-type="doi">10.24875/pjdv.m22000029</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[CLOVES syndrome in a six-month-old infant: The importance of cutaneous findings]]></article-title>
<article-title xml:lang="pt"><![CDATA[Síndrome de CLOVES em lactente de 6 meses: a importância das manifestações cutâneas]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alves]]></surname>
<given-names><![CDATA[Francisca]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morgado]]></surname>
<given-names><![CDATA[Francisca]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sousa]]></surname>
<given-names><![CDATA[Sérgio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramos]]></surname>
<given-names><![CDATA[Leonor]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Coimbra Hospital and University Center Dermatology Department ]]></institution>
<addr-line><![CDATA[Coimbra ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Coimbra Hospital and University Center Genetics Department ]]></institution>
<addr-line><![CDATA[Coimbra ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<volume>80</volume>
<numero>2</numero>
<fpage>138</fpage>
<lpage>141</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2795-50012022000200138&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2795-50012022000200138&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2795-50012022000200138&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract CLOVES syndrome is a rare overgrowth syndrome caused by an activating somatic mutation in the PIK3CA gene. We report the case of a six-month-old male that presented with a complex dermatosis with evolution since birth. Physical examination revealed a reticulated erythematous patch that affected the right anterior chest wall, where it showed sharp demarcation at the midline. He also had gigantism of the hands and feet, with an acral furrowing of the skin. Later on, he developed papillomatous plaque lesions in the cervical region, suggestive of epidermal nevi. Genetic study performed on lesional skin confirmed the PIK3CA mutation, establishing the diagnosis of CLOVES syndrome. The present case stands out given the rarity of this entity. Early differentiation between other overgrowth syndromes is important, namely because of the worse prognosis of Proteus. Moreover, we emphasize the importance of cutaneous findings and the dermatologist&#8217;s role in the diagnostic approach to such cases.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo O síndrome de CLOVES é um síndrome de hipercrescimento raro, causada por uma mutação somática ativadora no gene PIK3CA. Relatamos o caso de um menino de seis meses, que se apresentou com uma dermatose complexa, de evolução congénita. O exame físico revelou uma mancha eritematosa reticulada ocupando a parede torácica anterior à direita, onde apresentava demarcação muito bem delimitada na linha média. Apresentava ainda gigantismo nas mãos e nos pés, com aspecto &#8220;furrowed&#8221; acral. Posteriormente, desenvolveu lesões em placa papilomatosas na região cervical, sugestivas de nevo epidérmico. O estudo genético realizado na pele lesional confirmou a mutação PIK3CA, estabelecendo o diagnóstico de síndrome CLOVES. O presente caso destaca-se pela raridade desta entidade. A diferenciação precoce com outros síndromes de hipercrescimento é importante, principalmente por causa do pior prognóstico de Proteus. Além disso, realçamos a importância dos achados cutâneos e do papel do dermatologista na abordagem diagnóstica inicial destes casos.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[CLOVES]]></kwd>
<kwd lng="en"><![CDATA[Overgrowth syndrome]]></kwd>
<kwd lng="en"><![CDATA[Paediatric dermatology]]></kwd>
<kwd lng="pt"><![CDATA[CLOVES]]></kwd>
<kwd lng="pt"><![CDATA[Síndrome de sobrecrescimento]]></kwd>
<kwd lng="pt"><![CDATA[Dermatologia pediátrica]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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