<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0871-018X</journal-id>
<journal-title><![CDATA[Revista de Ciências Agrárias]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. de Ciências Agrárias]]></abbrev-journal-title>
<issn>0871-018X</issn>
<publisher>
<publisher-name><![CDATA[Sociedade de Ciências Agrárias de Portugal]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0871-018X2007000100042</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[As leguminosas como alimentos funcionais: o caso das dislipidémias e das doenças cardiovasculares]]></article-title>
<article-title xml:lang="en"><![CDATA[Legumes as functional foods: the case of dyslipidemia and cardiovascular diseases]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martins]]></surname>
<given-names><![CDATA[J.M.]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bento]]></surname>
<given-names><![CDATA[O.P.]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
</contrib-group>
<aff id="A01">
<institution><![CDATA[,Universidade de Évora Instituto de Ciências Agrárias Mediterrânicas (ICAM) ]]></institution>
<addr-line><![CDATA[Évora ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>01</month>
<year>2007</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>01</month>
<year>2007</year>
</pub-date>
<volume>30</volume>
<numero>1</numero>
<fpage>385</fpage>
<lpage>399</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0871-018X2007000100042&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0871-018X2007000100042&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0871-018X2007000100042&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[A dieta mediterrânica é rica em alimentos funcionais. As leguminosas, um dos alimentos-chave desta dieta, têm visto o seu papel na prevenção de dislipidémias, diabetes e cancro do cólon mencionado por muitos autores. O efeito do consumo de leguminosas na redução da colesterolémia deve-se a diferentes nutrientes e fitoquímicos, tais como: i) proteína; ii) lípidos, particularmente a componente polinsaturada e monoinsaturada; iii) fibra, especialmente a fracção solúvel; iv) saponinas; e v) fitosteróis. O consumo da soja tem sido relacionado com tais efeitos benéficos, mas dados recentes obtidos na Universidade de Évora demonstraram que leguminosas como a ervilha e o tremoço de folhas estreitas também apresentam elevado potencial funcional na regulação do colesterol sanguíneo. O seu consumo levou a reduções de 30% na colesterolémia de animais experimentais, via redução do colesterol das LDL. A utilização destas leguminosas como alimentos funcionais e/ou como fornecedoras de fitoquímicos com potencial preventivo e terapêutico é promissora e poderá constituir uma maisvalia e uma fonte extra de rendimento para os agricultores que se dediquem ao cultivo destas espécies.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[The Mediterranean diet is rich in functional foods. Legumes are one of the key-foods of this diet and many authors mention their role in the prevention of dyslipidemias, diabetes and colon cancer. The hypocholesterolemic effect of legumes is related to several nutrients and phytochemicals. Among them: i) protein; ii) lipids, especially polyunsaturated and monounsaturated ones; iii) dietary fibre, especially soluble fibre; iv) saponins; and v) phytosterols. Soybean consumption has been related with these benefic effects. However, recent data obtained at the University of Évora have demonstrated that other legumes, such as peas and blue lupin, can also present a high hypocholesterolemic potential. In fact, the consumption of these legumes led to a 30% reduction in the cholesterolemia of experimental animals, due to a LDL-cholesterol reduction. The utilization of these legumes as functional foods or as providers of phytochemicals with a high preventive and therapeutic potential is promising, and may contribute to an increase in the income of farmers growing these crops.]]></p></abstract>
</article-meta>
</front><body><![CDATA[ <p align="center"><b>As leguminosas como alimentos funcionais: o caso das dislipidémias    e das doenças cardiovasculares </b></p>     <p align="center"><b>Legumes as functional foods: the case of dyslipidemia and    cardiovascular diseases </b></p>     <p>&nbsp;</p>     <P align="center">J.M. Martins<Sup><a href="#1">1</a><a name="top1"></a></Sup>    &amp; O.P. Bento<Sup><a href="#1">1</a><a name="top1"></a> </Sup></P>     <p>&nbsp;</p>     <p align="center"><b>RESUMO </b></p>     <p>A dieta mediterrânica é rica em alimentos funcionais. As leguminosas, um dos    alimentos-chave desta dieta, têm visto o seu papel na prevenção de dislipidémias,    diabetes e cancro do cólon mencionado por muitos autores. O efeito do consumo    de leguminosas na redução da colesterolémia deve-se a diferentes nutrientes    e fitoquímicos, tais como: i) proteína; ii) lípidos, particularmente a componente    polinsaturada e monoinsaturada; iii) fibra, especialmente a fracção solúvel;    iv) saponinas; e v) fitosteróis. O consumo da soja tem sido relacionado com    tais efeitos benéficos, mas dados recentes obtidos na Universidade de Évora    demonstraram que leguminosas como a ervilha e o tremoço de folhas estreitas    também apresentam elevado potencial funcional na regulação do colesterol sanguíneo.    O seu consumo levou a reduções de 30% na colesterolémia de animais experimentais,    via redução do colesterol das LDL. A utilização destas leguminosas como alimentos    funcionais e/ou como fornecedoras de fitoquímicos com potencial preventivo e    terapêutico é promissora e poderá constituir uma maisvalia e uma fonte extra    de rendimento para os agricultores que se dediquem ao cultivo destas espécies.  </P>     <p>&nbsp;</p>     <p align="center"><b>ABSTRACT </b></p>     <p>The Mediterranean diet is rich in functional foods. Legumes are one of the    key-foods of this diet and many authors mention their role in the prevention    of dyslipidemias, diabetes and colon cancer. The hypocholesterolemic effect    of legumes is related to several nutrients and phytochemicals. Among them: i)    protein; ii) lipids, especially polyunsaturated and monounsaturated ones; iii)    dietary fibre, especially soluble fibre; iv) saponins; and v) phytosterols.    Soybean consumption has been related with these benefic effects. However, recent    data obtained at the University of Évora have demonstrated that other legumes,    such as peas and blue lupin, can also present a high hypocholesterolemic potential.    In fact, the consumption of these legumes led to a 30% reduction in the cholesterolemia    of experimental animals, due to a LDL-cholesterol reduction. The utilization    of these legumes as functional foods or as providers of phytochemicals with    a high preventive and therapeutic potential is promising, and may contribute    to an increase in the income of farmers growing these crops. </P>     ]]></body>
<body><![CDATA[<p>&nbsp;</p>     <p>Texto completo disponível apenas em PDF.</p>     <p>Full text only available in PDF format.</p>     <p>&nbsp;</p>     <p align="center"><b>REFERÊNCIAS BIBLIOGRÁFICAS </b></p>     <!-- ref --><p>Abadie, C., Hug, M., Kubli, C. &amp; Gains, N. 1994. Effect of cyclodextrins    and undigested starch on the loss of chenodeoxycholate in the faeces. <i>Biochemical    Journal</i>, <b>299</b>: 725-730. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000018&pid=S0871-018X200700010004200001&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><p>Alonso, R., Grant, G. &amp; Marzo, F. 2001. Thermal treatment improves nutritional    quality of pea seeds (<i>Pisum sativum</i> L.) without reducing their hypocholesterolemic    properties. <i>Nutrition Research</i>, <b>21</b>: 1067-1077. </P>     <p>Anderson, J.W. 2003. Whole grains protect against atherosclerotic cardiovascular    disease. <i>Proceedings of the Nutrition Society</i>, <b>62</b>: 135-142. </P>     <p>Anderson, J.W., Deakins, D.A., Floore, T.L., Smith, B.M. &amp; Whitis, S.E.    1990. Dietary fiber and coronary heart disease. <i>Critical Reviews in Food    Science and Nutrition</i>, <b>29</b>: 95-147. </P>     <p>Anderson, J.W., Jones, A.E. &amp; Riddell-Mason, S. 1994. Ten different dietary    fibers have significantly different effects on serum and liver lipids of cholesterol-fed    rats. <i>Journal of Nutrition</i>, <b>124</b>: 78-83. </P>     ]]></body>
<body><![CDATA[<p>Anderson, J.W. &amp; Major, A.W. 2002. Pulses and lipaemia, short-and long-term    effect: potential in the prevention of cardiovascular disease. <i>British Journal    of Nutrition</i>, <b>88</b>: s263-s271. </P>     <p>Anderson, J.W., Story, L., Sieling, B., Chen, W.-J.L., Petro, M.S. &amp; Story,    J. 1984. Hypocholesterolemic effects of oat-bran or bean intake for hypercholesterolemic    men. <i>American Journal of Clinical Nutrition</i>, <b>40</b>: 1146-1155. </P>     <p>Anthony, M.S., Clarkson, T.B., Bullock, B.C. &amp; Wagner, J.D. 1997. Soy protein    versus soy phytoestrogens in the prevention of diet-induced coronary artery    atherosclerosis of male cynomolgus monkeys. <i>Arteriosclerosis, Thrombosis,    and Vascular Biology</i>, <b>17</b>: 2524-2531. </P>     <p>Bingwen, L., Zhaofeny, W., Wanshen, L. &amp; Rongjue, Z. 1981. Effects of bean    meal on serum cholesterol and triglycerides. <i>Chinese Medical Journal</i>,    <b>94</b>: 455-458. </P>     <p>Champ, M.M. 2002. Non-nutrient bioactive substances of pulses. <i>British Journal    of Nutrition</i>, <b>88</b>: s307-s319. </P>     <p>Chang, K.C., Ethen, S., Harrold, R. &amp; Brown, G. 1986. Effect of feeding    dry beans on rat plasma-cholesterol. <i>Nutrition Reports International</i>,    <b>33</b>: 659-664. </P>     <p>Chango, A., Villaume, C., Bau, H.M., Schwertz, A., Nicolas, J.-P. &amp; Mejean,    L. 1998. Effects of casein, sweet white lupin and sweet yellow lupin diet on    cholesterol metabolism in rats. <i>Journal of the Science of Food and Agriculture</i>,    <b>76</b>: 303-309. </P>     <p>Combs, G.E., Conness, R.G., Berry, T.H. &amp; Wallace, H.D. 1967. Effect of    raw and heated soybeans on gain, nutrient digestibility, plasma amino acids    and other blood constituents of growing swine. <i>Journal of Animal Science</i>,    <b>26</b>: 1067-1071. </P>     <p>Costa, N.M.B., Low, A.G., Walker, A.F., Owen, R.W. &amp; Englyst, H.N. 1994.    Effect of baked beans (<i>Phaseolus vulgaris</i>) on steroid metabolism and    non-starch polysaccharide output of hypercholesterolaemic pigs with or without    an ileorectal anastomosis. <i>British Journal of Nutrition</i>, <b>71</b>: 871-886.  </P>     <p>Costa, N.M.B., Walker, A.F. &amp; Low, A.G. 1993. The effect of graded inclusion    of baked beans (<i>Phaseolus vulgaris</i>) on plasma and liver lipids in hypercholesterolaemic    pigs given a Western-type diet. <i>British Journal of Nutrition</i>, <b>70</b>:    515-524. </P>     ]]></body>
<body><![CDATA[<p>Craig, W.J. 1997. Phytochemicals: guardians of our health. <i>Journal of the    American Dietetic Association</i>, <b>97</b>: S199-S204. </P>     <p>Dabai, F.D., Walker, A.F., Sambrook, I.E., Welch, V.A., Owen, R.W. &amp; Abeyasekera,    S. 1996. Comparative effects on blood lipids and faecal steroids of five legume    species incorporated into a semi-purified, hypercholesterolaemic rat diet. <i>British    Journal of Nutrition</i>, <b>75</b>: 557-571. </P>     <p>Daumerie, C.M., Woollett, L.A. &amp; Dietschy, J.M. 1992. Fatty acids regulate    hepatic low density lipoprotein receptor activity through redistribution of    intracellular cholesterol pools. <i>Proceedings of the National Academy of Sciences    USA</i>, <b>89</b>: 10797-10801. </P>     <p>Devi, K.S. &amp; Kurup P.A. 1970. Effect of certain Indian pulses on the serum,    liver and aortic lipid levels in rats fed a hypercholesterolaemic diet. <i>Atherosclerosis</i>,    <b>11</b>: 479-484. </P>     <p>Duane, W.C. 1997. Effects of legume consumption on serum cholesterol, biliary    lipids, and sterol metabolism in humans. <i>Journal of Lipid Research</i>, <b>38</b>:    1120-1128. </P>     <p>FAO statistics 2005. <a href="http://faostat.fao.org/" target="_blank">http://faostat.fao.org/</a>    (Último acesso em Novembro de 2005). </P>     <p>Finnigan, T.J. 1983. The effect of whole and air-classified legumes on serum    lipids in hypercholesterolemic rabbits. <i>Journal of the Science of Food and    Agriculture</i>, <b>34</b>: 275-276. </P>     <p>Forsythe, W.A., Green, M.S. &amp; Anderson, J.J. 1986. Dietary protein effects    on cholesterol and lipoprotein concentrations: a review. <i>Journal of the American    College of Nutrition</i>, <b>5</b>: 533-549. </P>     <p>Frost, G., Leeds, A.A., Doré, C.J., Madeiros, S., Brading, S. &amp; Dornhorst,    A. 1999. Glycaemic index as a determinant of serum HDL-cholesterol concentration.    <i>The Lancet</i>, <b>353</b>: 1045-1048. </P>     <p>Fruhbeck, G., Monreal, I. &amp; Santidrian, S. 1997. Hormonal implications    of the hypocholesterolemic effect of intake of field beans (<i>Vicia faba</i>    L.) by young men with hypercholesterolemia. <i>American Journal of Clinical    Nutrition</i>, <b>66</b>: 1452-1460. </P>     ]]></body>
<body><![CDATA[<p>German, J.B. &amp; Watkins, S.M. 2004. Metabolic assessment - a key to nutritional    strategies for health. <i>Trends in Food Science &amp; Technology</i>, <b>15</b>:    541-549. </P>     <p>Hasler, C.M. 2002. Functional foods: Benefits, concerns and challenges - A    position paper from the American Council on Science and Health. <i>Journal of    Nutrition</i>, <b>132</b>: 3772-3781. </P>     <p>Hicks, K.B. &amp; Moreau, R.A. 2001. Phytosterols and phytostanols: Functional    food cholesterol busters. <i>Food Technology</i>, <b>55</b>: 63-67. </P>     <p>Holm, F. 2003. New functional food ingredients. <i>Cardiovascular Health.</i>    SMEs nº5. Flair-flow 4. </P>     <p>Ikeda, I., Tanaka, K., Sugano, M., Vahouny, V. &amp; Gallo, L.L. 1988. Inhibition    of cholesterol absorption in rats by plant sterols. <i>Journal of Lipid Research</i>,    <b>29</b>: 1573-1582. </P>     <p>Illingworth, D.R. 1988. Drug therapy of hypercholesterolemia. <i>Clinical Chemistry</i>,    <b>34</b>: B123-B132. </P>     <p>Jeffery, E. 2005. Component interactions for efficacy of functional foods.    <i>Journal of Nutrition</i>, <b>135</b>: 1223-1225. </P>     <p>Jenkins, D.J., Kendall, C.W., Faulkner, D., Vidgen, E., Trautwein, E.A., Parker,    T.L., Marchie, A., Koumbridis, G., Lapsley, K.G., Josse, R.G., Leiter, L.A.    &amp; Connelly, P.W. 2002. A dietary portfolio approach to cholesterol reduction:    combined effects of plant sterols, vegetable proteins, and viscous fibers in    hypercholesterolemia. <i>Metabolism</i>, <b>51</b>: 1596-1604. </P>     <p>Jenkins, D.J., Newton, C., Leeds, A.R. &amp; Cummings, J.H. 1975. Effect of    pectin, guar gum, and wheat fibre on serum-cholesterol. <i>The Lancet</i>, <b>1</b>:    1116-1117. </P>     <p>Jenkins, D.J., Wong, G.S., Patten, R., Bird, J., Hall, M., Buckley, G.C., McGuire,    V., Reichert, R. &amp; Little, J.A. 1983. Leguminous seeds in the dietary management    of hyperlipidemia. <i>American Journal of Clinical Nutrition</i>, <b>38</b>:    567-573. </P>     ]]></body>
<body><![CDATA[<p>Jones, P.J. 2002. Clinical nutrition: 7. Functional foods - more than just    nutrition. <i>Canadian Medical Association Journal</i>, <b>166</b>: 1555-1563.  </P>     <p>Kabagambe, E.K., Baylin, A., Ruiz-Narvarez, E., Siles, X. &amp; Campos, H.    2005. Decreased consumption of dried mature beans is positively associated with    urbanization and nonfatal acute myocardial infarction. <i>Journal of Nutrition</i>,    <b>135</b>: 1770-1775. </P>     <p>Kingman, S.M. 1991. The influence of legume seeds on human plasma lipid concentrations.    <i>Nutrition Research Reviews</i>, <b>4</b>: 97-123. </P>     <p>Kingman, S.M., Walker, A.F., Low, A.G., Sambrook, I.E., Owen, R.W. &amp; Cole,    T.J. 1993. Comparative effects of four legume species on plasma lipids and faecal    steroid excretion in hypercholesterolaemic pigs. <i>British Journal of Nutrition</i>,    <b>69</b>: 409-421. </P>     <p>Kreuzer, M., Hanneken, H., Wittmann, M., Gerdemann, M.M. &amp; Machmüller,    A. 2002. Effects of different fibre sources and fat addition on cholesterol    and cholesterol-related lipids in blood serum, bile and body tissues of growing    pigs. <i>Journal of Animal Physiology and Animal Nutrition</i>, <b>86</b>: 57-73.  </P>     <p>Kris-Etherton, P., Eckel, R.H., Howard, B.V., St. Jeor, S., Bazzarre, T.L.    &amp; Nutrition Committee Population Science Committee and Clinical Science    Committee of the American Heart Association 2001. AHA Science Advisory: Lyon    Diet Heart Study. Benefits of a Mediterranean-style, National Cholesterol Education    Program/American Heart Association Step I Dietary Pattern on Cardiovascular    Disease. <i>Circulation</i>, <b>103</b>: 1823-1825. </P>     <p>Kritchevsky, D. 1979. Vegetable protein and atherosclerosis. <i>Journal of    the American Oil Chemists’ Society</i>, <b>56</b>: 135-146. </P>     <p>Kritchevsky, D. 1987. Dietary fiber and lipid metabolism. <i>International    Journal of Obesity</i>, <b>11</b>: 33-43. </P>     <p>Lin, Y., Meijer, G.W., Vermeer, M.A. &amp; Trautwein, E.A. 2004. Soy protein    enhances the cholesterol-lowering effect of plant sterol esters in cholesterol-fed    hamsters. <i>Journal of Nutrition</i>, <b>134</b>: 143-148. </P>     <p>Ling, W.H. &amp; Jones, P.J.H. 1995. Dietary phytosterols: a review of metabolism,    benefits and side effects. <i>Life Sciences</i>, <b>57</b>: 195-206. </P>     ]]></body>
<body><![CDATA[<p>Lipid Research Clinics Program 1984. The lipid research clinic coronary primary    prevention trial results. 1: Reduction in the incidence of coronary heart disease.    <i>Journal of the American Medical Association</i>, <b>251</b>: 351-364. </P>     <p>Macarulla, M.T., Medina, C., Diego, M.A.D., Chavarri, M., Zulet, M.A., Martinez,    J.A., Noel-Suberville, C., Higueret, P. &amp; Portillo, M.P. 2001. Effects of    the whole seed and a protein isolate of faba bean (<i>Vicia faba</i>) on the    cholesterol metabolism of hypercholesterolaemic rats. <i>British Journal of    Nutrition</i>, <b>85</b>: 607-614. </P>     <p>Madar, Z. &amp; Stark, A.H. 2002. New legume sources as therapeutic agents.    <i>British Journal of Nutrition</i>, <b>88</b>: s287-s292. </P>     <p>Martins, J.M., Riottot, M., Abreu, M.C., Lança, M.J., Viegas-Crespo, A.M.,    Almeida, J.A., Freire, J.B. &amp; Bento, O.P. 2004. Dietary raw peas (<i>Pisum    sativum</i> L.) reduce plasma total and LDL cholesterol and hepatic esterified    cholesterol in intact and ileorectal anastomosed pigs fed cholesterol-rich diets.    <i>Journal of Nutrition</i>, <b>134</b>: 3305-3312. </P>     <p>Martins, J.M., Riottot, M., Abreu, M. C., Viegas-Crespo, A.M., Lança, M.J.,    Almeida, J.A., Freire, J.B. &amp; Bento, O.P. 2005. Cholesterol-lowering effects    of dietary blue lupin (<i>Lupinus angustifolius</i> L.) in intact and ileorectal    anastomosed pigs. <i>Journal of the Lipid Research</i>, <b>46</b>: 1539-1547.  </P>     <p>Mathur, K.S., Khan, M.A. &amp; Sharma, R.D. 1968. Hypocholesterolaemic effect    of Bengal gram: a long-term study in man. <i>British Medical Journal</i>, <b>1</b>:    30-31. </P>     <p>Mathur, K.S., Sharma, R.D. &amp; Singhal, S.S. 1964. Effect of Bengal gram    on experimentally induced high levels of cholesterol in tissues and serum in    albino rats. <i>Journal of Nutrition</i>, <b>84</b>: 201-204. </P>     <p>Merritt, J.C. 2004. Metabolic syndrome: soybean foods and serum lipids. <i>Journal    of the National Medical Association</i>, <b>96</b>: 1032-1041. </P>     <p>Nervi, F., Covarrubias, C., Bravo, P., Velasco, N., Ulloa, N., Cruz, F., Fava,    M., Severin, C., Pozo, R.D., Antezana, C., Valdivieso, V. &amp; Arteaga, A.    1989. Influence of legume intake on biliary lipids and cholesterol saturation    in young Chilean men. Identification of a dietary risk factor for cholesterol    gallstone formation in a highly prevalent area. <i>Gastroenterology</i>, <b>96</b>:    825-830. </P>     <p>Oakenfull, D.G. 1981. Saponins in food: a review. <i>Food Chemistry</i>, <b>7</b>:    19-40. </P>     ]]></body>
<body><![CDATA[<p>Ramos, A., Bento, O., Lança, M.J., Capela e Silva, F., Martins, J.M. &amp;    Freitas, A. 2005. Estudo histopatológico de lesões ateroscleróticas em suínos    de raça Alentejana. <i>Jornadas ICAM 2005</i>, pp. 137-138. ICAM, Évora, Portugal.  </P>     <p>Rigotti, A., Marzolo, M.P., Ulloa, N., Gonzalez, O. &amp; Nervi, F. 1989. Effect    of bean intake on biliary lipid secretion and on hepatic cholesterol metabolism    in the rat. Journal of Lipid Research, <b>30</b>: 1041-1048. </P>     <p>Rosa, C.O., Costa, N.M., Leal, P.F. &amp; Oliveira, T.T. 1998. Efeito do feijão    preto (<i>Phaseolus vulgaris</i>, L.) sem casca na redução do colesterol sanguíneo    de ratos hipercolesterolémicos. <i>Archivos Latinoamericanos de Nutricion</i>,    <b>48</b>: 299-305. </P>     <p>Rubio, L.A., Brenes, A. &amp; Centeno, C. 2003. Effects of feeding growing    broiler chickens with practical diets containing sweet lupin (<i>Lupinus angustifolius</i>)    seed meal. <i>British Poultry Science</i>, <b>44</b>: 391-397. </P>     <p>Sarathy, R. &amp; Saraswathi, G. 1983. Effect of tender cluster bean pods (<i>Cyamopsis    tetragonoloba</i>) on cholesterol levels in rats. <i>American Journal of Clinical    Nutrition</i>, <b>38</b>: 295-299. </P>     <p>Setchell, K.D. &amp; Radd, S. 2000. Soy and other legumes: 'Bean' around a    long time but are they the 'superfoods' of the millennium and what are the safety    issues for their constituent phytoestrogens? <i>Asia Pacific Journal of Clinical    Nutrition</i>, <b>9</b>: s13-s22. </P>     <p>Shutler, S.M., Bircher, G.M., Tredger, J.A., Morgan, L.M., Walker, A.F. &amp;    Low, A.G. 1989. The effect of daily baked bean (Phaseolus vulgaris) consumption    on the plasma lipid levels of young, normo-cholesterolaemic men. <i>British    Journal of Nutrition</i>, <b>61</b>: 257-265. </P>     <p>Shutler, S.M., Walker, A.F. &amp; Low, A.G. 1987a. The cholesterol-lowering    effects of legumes. I. Effects of the major nutrients. <i>Human Nutrition: Food    Sciences and Nutrition</i>, <b>41F</b>: 71-86. </P>     <p>Shutler, S.M., Walker, A.F. &amp; Low, A.G. 1987b. The cholesterol-lowering    effects of legumes. II. Effects of fibre, sterols, saponins and isoflavones.    <i>Human Nutrition: Food Sciences and Nutrition</i>, <b>41F</b>: 87-102. </P>     <p>Soni, G.L., George M. &amp; Singh, R. 1982. Role of common Indian pulses as    hypocholesterolaemic agents. <i>Indian Journal of Nutrition and Dietetics</i>,    <b>19</b>: 184-190. </P>     ]]></body>
<body><![CDATA[<p>Sowmya, P. &amp; Rajyalakshmi, P. 1999. Hypocholesterolemic effect of germinated    fenugreek seeds in human subjects. <i>Plant Foods for Human Nutrition</i>, <b>53</b>:    359-365. </P>     <p>Thomas, P.R. &amp; Earl, R. 1994. <i>Opportunities in the Nutrition and Food    Sciences.</i> Institute of Medicine/National Academy of Sciences, National Academy    Press, Washington, DC. </P>     <p>Topping, D.L. 1991. Soluble fiber polysaccharides: effects on plasma cholesterol    and colonic fermentation. <i>Nutrition Reviews</i>, <b>49</b>: 195-203. </P>     <p>Trichopoulou, A., Naska, A., Orfanos, P. &amp; Trichopoulos, D. 2005. Mediterranean    diet in relation to body mass index and waist-to-hip ratio: the Greek European    Prospective Investigation into Cancer and Nutrition Study. <i>American Journal    of Clinical Nutrition</i>, <b>82</b>: 935-940. </P>     <p>Vahouny, G.V., Tombes, R., Cassidy, M.M., Kritchevsky, D. &amp; Gallo, L.L.    1980. Dietary fibers: V. Binding of bile salts, phospholipids and cholesterol    from mixed micelles by bile acid sequestrants and dietary fibers. <i>Lipids</i>,    <b>15</b>: 1012-1018. </P>     <p>Venter, C.S. &amp; van Eyssen, E. 2001. More legumes for better overall health.    <i>South African Journal of Clinical Nutrition</i>, <b>14</b>: s32-s38. </P>     <p>Vitic, J. &amp; Stevanovic, J. 1993. Comparative studies of the serum lipoproteins    and lipids in some domestic, laboratory and wild animals. <i>Comparative Biochemistry    and Physiology. B: Biochemistry and Molecular Biology</i>, <b>106</b>: 223-229.  </P>     <p>Wang, Y.H. &amp; McIntosh, G.H. 1996. Extrusion and boiling improve rat body    weight gain and plasma cholesterol lowering ability of peas and chickpeas. <i>Journal    of Nutrition</i>, <b>126</b>: 3054-3062. </P>     <p>Willett, W.C., Sacks, F., Trichopoulou, A., Drescher, G., Ferro-Luzzi, A.,    Helsing, E. &amp; Trichopoulos, D. 1995. Mediterranean diet pyramid: a cultural    model for healthy eating. <i>American Journal of Clinical Nutrition</i>, <b>61</b>:    1402S-1406S. </P>     <p>Woollett, L.A., Spady, D.K. &amp; Dietschy, J.M. 1992. Saturated and unsaturated    fatty acids independently regulate low density lipoprotein receptor activity    and production rate. <i>Journal of Lipid Research</i>, <b>33</b>: 77-88. </P>     ]]></body>
<body><![CDATA[<p>Würsch, P., Del Vedovo, S. &amp; Koellreutter, B. 1986. Cell structure and    starch nature as key determinants of the digestion rate of starch in legume.    <i>American Journal of Clinical Nutrition</i>, <b>43</b>: 25-29. </P>     <p>&nbsp;</p>     <p><Sup><a href="#top1">1</a><a name="1"></a> </Sup>Instituto de Ciências Agrárias    Mediterrânicas, Universidade de Évora, 7002-554 Évora, e-mail: <a href="mailto:jmartins@uevora.pt">jmartins@uevora.pt</a>  </P>      ]]></body><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Abadie]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Hug]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Kubli]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Gains]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[Effect of cyclodextrins and undigested starch on the loss of chenodeoxycholate in the faeces.]]></article-title>
<source><![CDATA[Biochemical Journal]]></source>
<year>1994</year>
<volume>299</volume>
<page-range>725-730</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
