<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0871-018X</journal-id>
<journal-title><![CDATA[Revista de Ciências Agrárias]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. de Ciências Agrárias]]></abbrev-journal-title>
<issn>0871-018X</issn>
<publisher>
<publisher-name><![CDATA[Sociedade de Ciências Agrárias de Portugal]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0871-018X2023000500251</article-id>
<article-id pub-id-type="doi">10.19084/rca.33414</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Genotoxicidade na minhoca Eisenia fetida exposta a metafedrona e cetamina]]></article-title>
<article-title xml:lang="en"><![CDATA[Genotoxicity on earthworm Eisenia fetida exposed to metaphedrone and ketamine]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ribeiro]]></surname>
<given-names><![CDATA[Ondina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Natal-da-Luz]]></surname>
<given-names><![CDATA[Tiago]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ribeiro]]></surname>
<given-names><![CDATA[Cláudia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sousa]]></surname>
<given-names><![CDATA[João Ricardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gaivão]]></surname>
<given-names><![CDATA[Isabel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carrola]]></surname>
<given-names><![CDATA[João Soares]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e Tecnologias Agroambientais e Biológicas (CITAB/ Inov4Agro) ]]></institution>
<addr-line><![CDATA[Vila Real ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Universitário de Ciências da Saúde Unidade de Investigação em Toxicologia &amp; Uma Só Saúde (1H-TOXRUN) ]]></institution>
<addr-line><![CDATA[Gandra ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidade de Coimbra Centro de Ecologia Funcional ]]></institution>
<addr-line><![CDATA[Coimbra ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,UTAD Centro de Ciência Animal e Veterinária (CECAV) ]]></institution>
<addr-line><![CDATA[Vila Real ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<volume>46</volume>
<numero>sp</numero>
<fpage>251</fpage>
<lpage>260</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0871-018X2023000500251&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0871-018X2023000500251&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0871-018X2023000500251&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo A metafedrona e a cetamina são duas substâncias psicoativas (SPAs) utilizadas para fins recreativos e que podem ser detetadas nos ecossistemas terrestres devido à irrigação dos solos com águas contaminadas, aplicação de lamas provenientes de estações de tratamento de águas residuais, entre outros. Apesar de chegarem aos solos, pouco se sabe acerca dos efeitos tóxicos que as SPAs podem induzir nos organismos terrestres e na ecologia do solo. Assim, o objetivo deste trabalho centrou-se na avaliação dos efeitos genotóxicos da metafedrona e da cetamina na minhoca Eisenia fetida, após um período de exposição de 28 dias. Observou-se que a metafedrona induziu efeitos significativos no ADN para a concentração de 2500 µg/kg, enquanto que a cetamina causou danos no ADN para as concentrações de 250 e 2500 µg/kg. Desta forma, concluiu-se que estas duas SPAs são genotóxicas para esta espécie, mas apenas a concentrações elevadas. Mais estudos são necessários de forma a perceber quais as vias metabólicas que podem induzir estes efeitos no ADN, como por exemplo ao nível do stresse oxidativo das minhocas e as consequências que poderá ter ao nível da defesa imunológica e na dinâmica das suas populações.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Metaphedrone and ketamine are two psychoactive substances (PAS) used for recreational purposes that can be detected in terrestrial ecosystems due to soil irrigation with contaminated water, application of sludge from wastewater treatment plants, among others. Despite reaching soils, little is known about the toxic effects that PAS can induce on terrestrial organisms and soil ecology. Thus, the objective of this work was centred on the evaluation of the genotoxic effects of metaphedrone and ketamine on the earthworm Eisenia fetida, after an exposure period of 28 days. It was observed that metaphedrone induced significant DNA effects at the 2500 µg/kg concentration, whereas ketamine caused DNA damage at the 250 and 2500 µg/kg concentrations. Thus, it was concluded that these two PAS are genotoxic for this species, but only at high concentrations. More studies are needed in order to understand which metabolic pathways can induce these effects in DNA, such as the level of oxidative stress in earthworms and the consequences it may have in terms of immune defence and in the dynamics of their populations.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Minhocas]]></kwd>
<kwd lng="pt"><![CDATA[genotoxicidade]]></kwd>
<kwd lng="pt"><![CDATA[metafedrona]]></kwd>
<kwd lng="pt"><![CDATA[cetamina]]></kwd>
<kwd lng="pt"><![CDATA[solo]]></kwd>
<kwd lng="en"><![CDATA[Earthworms]]></kwd>
<kwd lng="en"><![CDATA[genotoxicity]]></kwd>
<kwd lng="en"><![CDATA[metaphedrone]]></kwd>
<kwd lng="en"><![CDATA[ketamine]]></kwd>
<kwd lng="en"><![CDATA[soil]]></kwd>
</kwd-group>
</article-meta>
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