Caso Clínico e Revisão da Literatura
Luísa Valle*; Patrícia Pinto†; Sofia Pimenta†; Manuela Dias*; Fernando Príncipe‡; Rui de Sousa*
Serviços de *Medicina A; †Reumatologia e ‡ Hematologia Clínica do Hospital de São João, Porto.
A doença de Castleman é uma entidade linfoproliferativa atípica, pouco frequente, com evolução crónica e sintomas inespecíficos. Os autores apresentam um caso clínico de doença de Castleman do tipo misto, de localização retroperitoneal cuja manifestação inicial foi uma anemia hemolítica autoimune por anticorpos frios. Fazem ainda uma revisão dos diferentes subtipos da doença, formas de apresentação, abordagem diagnóstica e terapêutica.
Palavras-chave: Doença de Castleman, forma localizada, forma multicêntrica.
]]> Retroperitoneal Castleman’s Disease
Castleman´s disease is an atypical lymphoproliferative disorder, relatively rare, with chronic evolution and nonspecific symptoms. We report a case of retroperitoneal mixed histologic type Castleman´s disease with cold haemolytic anemia as initial clinical manifestation. We also review the different subtypes, clinical presentation, diagnostic and therapeutic approach.
Key-words: Castleman´s disease, unicentric form, multicentric form.
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REFERÊNCIAS
1- Brown JR, Harris NL, Freedman AS. Castleman´s disease. UpToDate 2005 (800) 998-6374• (781) 237-4788. Disponível em: http://www.uptodate.com [ Links ]
2 - Castleman B, Menendez VP. Localized mediatinal lymph-node hyperplasia resembling thymoma. Cancer 1956;9:822-30.
]]> 3 - Herrada J, Cabanillas F, Rice L, et al. The clinical behavior of localized and multicentric Castleman disease. Ann Intern Med 1998;128:657-62.4 - Hamidou M, Gaillard F, Bataille R. Maladie de Castleman. In: Kahn MF, Peltier AP, Meyer O, Piette JC, editors. Maladies et syndromes systémiques. 4e ed. Paris: Flammarion Médicine-Sciences; 2000. p. 1105 - 13.
5 -Keller AR, Hochholzer L, Castleman B. Hyaline-vascular and plasma -cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer 1972; 29: 670-83.
6 - Herrada J, Cabanillas F. Multicentric Castleman´s disease. Am J. Oncol 1995;18:180-3.
7 - Peterson BA, Frizzera G. Multicentric Castleman´s disease. Semin Oncol 1993;20:636-47.
8 - Schunemann Jr. E, Urban CA, et al. Doença de Castleman Retroperitoneal - Relato de um caso e revisão da literatura. Acta Oncol Brazileira (online Art 07/00). Disponível em: http://www.hcanc.org.br/acta2k_7.html
9 - Beck JT, Hsu S, Wijdenes J, et al. Alleviation of systemic manifestations of Castleman´s disease by monoclonal anti-interleukin 6 antibody. N. Engl J Med 1994;330:602-5.
10 - Leger-Ravet MB, Peuchmaur M, Devergne O, et al. Interleukin 6 gene expression in Castleman´s disease. Blood 1991;78:2923-30.
11 -Hsu SM, Waldron JA, Xie SS, et al. Expression of interleukin 6 in Castleman´s disease. Hum Pathol 1993;24:833-9.
12 - Maslovsky I, Uriev L, Lugassy G. The heterogeneity of Castleman Disease: Report of five cases and review of the literature. Am J Med Sci 2000;320:292-5.
]]> 13 - Burger R, Neipel F, Fleckenstein B. et al. Human hepesvirus type 8 interleukin-6 homologue is functionally active on human myeloma cells. Blood 1998;91:1858-63.14 - Briz M, Martín T, Yebra M, Laguna P, Busto MJ, Fernández MN. Detección del herpesvirus humano 8 en pacientes con sarcoma de Kaposi o enfermedad de Castleman asociados al sida. Med Clin (Barc) 1998;110:662-664.
15 - Vallina E, Fresno M, Colunga D, Díaz J, Arribas JM. Enfermedad de Castleman: un concepto histológico para un amplio abanico clínico. An Med Intern 1996;13:232-4.
16 - Sarrot-Reynauld F. Castleman´s disease. Orphanet encyclopedia, August 2001. Disponível em: http://orphanet.infobiogen.fr
17 - Álvaro T, Martínez S, Font L, Contreras E. Enfermedad de Castleman: asociación histomorfológica com enfermedad de Hodgkin. Med Clin 1995;105:275-6
18 - Lachant NA, Sun NC, Leong LA, Oseas RS, Prince HE. Multicentric angiofollicular lymph node hyperplasia (Castleman´s disease) followed by Kaposi´s sarcoma in two homosexual males with the acquired immunodeficiency syndrome (AIDS). Am J Clin Pathol 1985; 83:27-33.
19 - Chen KTK. Multicentric Castleman´s Disease and Kaposi´s sarcoma. Am J Surg Pathol 1984;8:287-93.
20 - Loe MJ, Camoniano JK, Habermann TM, Menke D. Castleman´s Disease: The Mayo Clinic experience. A Reveiw of 90 Cases Spanning 54 Years. Blood 2002; 100(11), ASH Meeting abstracts.
21 - Gaba AR, Stein RS, Sweet DL, Variakojis D. Multicentric giant lymph node hyperplasia. Am J Clin Pathol 1978;69:86-90.
22 - Libson E, Fields S, Strauss S. Widespread Castleman disease CT and US findings. Radilogy 1988;166:753-5.
]]> 23 - Ribas A, Ribas-Mundó M. Enfermedad de Castleman multicêntrica. Aspectos actuales de su patogenia y tratamiento. Sangre 1995;40:401-6.24 - Veldhuis GJ, Van der Leest AHD, De Wolf JTM, De Vries EGE, Vellenga E. A case of localized Castleman´s disease with sistemic involvement: treatment an pathogenetic aspects. Ann Hematol 1996;73:47-50.
25 - Repetto L, Jaiprakashi MP, Selby PJ. Agressive angiofollicular lymph node hyperplasia (Castleman´s disease) treated with high dose melphalan and autologous bone marrow transplantation. Hematol Oncol 1986;4:213-7.
26 - Alonso M, Artiach G, Fernández A, Luna P. Enfermedade de Castleman. Aten Primaria 1991;8:583-4.
27 - Vaset M, Katzin WE, Mendelsohn G, Reydman M. Report of a case of localizated Castleman´s disease with progresion to malignant lymphoma. Am J Clin Pathol 1992;98:633-6.
Correspondência:
Dr.ª Luisa Valle
Serviço de Medicina A
Hospital de São João
]]> Alameda Prof. Hernâni Monteiro4200-319 Porto
e-mail: luisavalle@sapo.pt
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