<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0871-3413</journal-id>
<journal-title><![CDATA[Arquivos de Medicina]]></journal-title>
<abbrev-journal-title><![CDATA[Arq Med]]></abbrev-journal-title>
<issn>0871-3413</issn>
<publisher>
<publisher-name><![CDATA[ArquiMed - Edições Científicas AEFMUP ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0871-34132005000100006</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Epilepsia e gravidez: que conduta? A propósito de um caso clínico]]></article-title>
<article-title xml:lang="en"><![CDATA[Epilepsy and pregnancy: what management?]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodrigues]]></surname>
<given-names><![CDATA[Carla Tovim]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Branco]]></surname>
<given-names><![CDATA[Miguel]]></given-names>
</name>
<xref ref-type="aff" rid="A02"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[Isabel]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Estanqueiro]]></surname>
<given-names><![CDATA[Paula]]></given-names>
</name>
<xref ref-type="aff" rid="A02"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vicente]]></surname>
<given-names><![CDATA[Teresa]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[Isabel]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Couceiro]]></surname>
<given-names><![CDATA[Ana]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramos]]></surname>
<given-names><![CDATA[Conceição]]></given-names>
</name>
<xref ref-type="aff" rid="A03"/>
</contrib>
</contrib-group>
<aff id="A01">
<institution><![CDATA[,Maternidade Bissaya-Barreto Serviço de Obstetrícia/Ginecologia ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="A02">
<institution><![CDATA[,Maternidade Bissaya-Barreto Serviço de Neonatologia ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="A03">
<institution><![CDATA[,Hospital Pediátrico de Coimbra Serviço de Pediatria ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>01</month>
<year>2005</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>01</month>
<year>2005</year>
</pub-date>
<volume>19</volume>
<numero>1-2</numero>
<fpage>39</fpage>
<lpage>41</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0871-34132005000100006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0871-34132005000100006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0871-34132005000100006&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[A epilepsia representa a patologia neurológica mais comum durante a gravidez. Na maioria dos casos decorre sem intercorrências mas o risco obstétrico e de complicações neonatais está aumentado. Os antiepilépticos estão associados a um risco duas a três vezes maior de malformações major. Os autores apresentam o caso clínico de uma grávida com epilepsia desde os 20 anos de idade e de difícil controlo. A primeira gravidez, na qual esteve medicada com valproato de sódio, terminou às 23 semanas de gestação por diagnóstico de espinha bífida. Posteriormente foi medicada em pré-concepcional com carbamazepina e suplementos de ácido fólico. Engravidou após um bom controlo da doença, tendo esta gravidez decorrido sem complicações.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Epilepsy is the most common neurological disturbance during pregnancy. The vast majority of these pregnancies are uncomplicated, but there are increased obstetric risks and increased adverse neonatal outcomes compared with the general population. Antiepileptic treatment during pregnancy is associated with two to three-fold increase in the rate of major congenital anomalies. The authors present a case report of a pregnant woman with epilepsy since 20 years old, with difficult control of seizures. The first pregnancy, in witch she was treated with valproate, was terminated at 23 weeks’ gestation because the fetus developed a spina bifida. In a pre conceptional consultancy she was treated with carbamazepina and acid folic supplementation. She get pregnant after a good control of the disease, and had a healthy child.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[gravidez]]></kwd>
<kwd lng="pt"><![CDATA[epilepsia]]></kwd>
<kwd lng="pt"><![CDATA[vigilância pré-natal]]></kwd>
<kwd lng="pt"><![CDATA[anti-epilépticos]]></kwd>
<kwd lng="pt"><![CDATA[defeitos do tubo neural]]></kwd>
<kwd lng="pt"><![CDATA[profilaxia com ácido fólico]]></kwd>
<kwd lng="en"><![CDATA[pregnancy]]></kwd>
<kwd lng="en"><![CDATA[epilepsy]]></kwd>
<kwd lng="en"><![CDATA[prenatal screening]]></kwd>
</kwd-group>
</article-meta>
</front><body><![CDATA[ <P><B>Epilepsia e Gravidez: Que Conduta? </B></P>      <P>A Propósito de Um Caso Clínico </P>      <P>&nbsp;</P>      <P>Carla Tovim Rodrigues*; Miguel Branco†, Isabel Ferreira*; Paula Estanqueiro†;    Teresa Vicente*; Isabel Silva*; Ana Couceiro*; Conceição Ramos‡ </P>      <P>&nbsp;</P>      <P>Serviços de *Obstetrícia/Ginecologia e ‡Neonatologia da Maternidade Bissaya-Barreto;    †Serviço de Pediatria do Hospital Pediátrico de Coimbra. </P>      <P>&nbsp;</P>      <P align="justify">A epilepsia representa a patologia neurológica mais comum durante    a gravidez. Na maioria dos casos decorre sem intercorrências mas o risco obstétrico    e de complicações neonatais está aumentado. Os antiepilépticos estão associados    a um risco duas a três vezes maior de malformações major. Os autores apresentam    o caso clínico de uma grávida com epilepsia desde os 20 anos de idade e de difícil    controlo. A primeira gravidez, na qual esteve medicada com valproato de sódio,    terminou às 23 semanas de gestação por diagnóstico de espinha bífida. Posteriormente    foi medicada em pré-concepcional com carbamazepina e suplementos de ácido fólico.    Engravidou após um bom controlo da doença, tendo esta gravidez decorrido sem    complicações.</P>      <P align="justify"><b>Palavras-chave:</b> gravidez, epilepsia, vigilância pré-natal,    anti-epilépticos, defeitos do tubo neural, profilaxia com ácido fólico. </P>      <P>&nbsp;</P>      ]]></body>
<body><![CDATA[<P><B>Epilepsy and Pregnancy: What Management? </B></P>      <P>Epilepsy is the most common neurological disturbance during pregnancy. The    vast majority of these pregnancies are uncomplicated, but there are increased    obstetric risks and increased adverse neonatal outcomes compared with the general    population. Antiepileptic treatment during pregnancy is associated with two    to three-fold increase in the rate of major congenital anomalies. The authors    present a case report of a pregnant woman with epilepsy since 20 years old,    with difficult control of seizures. The first pregnancy, in witch she was treated    with valproate, was terminated at 23 weeks’ gestation because the fetus developed    a spina bifida. In a pre conceptional consultancy she was treated with carbamazepina    and acid folic supplementation. She get pregnant after a good control of the    disease, and had a healthy child.</P>      <P><b>Key-words:</b> pregnancy, epilepsy, prenatal screening, </P>      <P>&nbsp;</P>     <P>Texto completo disponível apenas em PDF.</P>     <P>Full text only available in PDF format.</P>     <P>&nbsp;</P>      <P><b>REFERÊNCIAS</b></P>      <!-- ref --><P>1 - Kilpatrick CJ, Hopper JL. O efeito exercido pela gravidez sobre a epilepsia,    segundo um estudo de 37 gravidezes. Revista de Obstetrícia e Ginecologia 1994;17:373-5.  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000021&pid=S0871-3413200500010000600001&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><P>2 - Page B, Pennell MD. Pregnancy in woman with epilepsy: maternal and fetal    outcomes. Seminars in Neurology 2002; 22:299-307. </P>     ]]></body>
<body><![CDATA[<P>3 - Waters CH, Belai Y, Gottps, et al. Outcomes of pregnancy associated with    antiepileptic drugs. Arch Neurol 1994;51:250-3.      <P>4 - Holmes LB, Harvey EA, Coull BA, et al. The teratogenicity of anticonvulsivant    drugs. N Engl J M 2001;344:1132-8. </P>     <P>5 - Ornoy A, Cohen E. Outcome of children born to epileptic mothers treated    with carbamazepine during pregnancy. Archives of Disease in Childhood 1996;75:517-20.  </P>     <P>6 - Jones KL, Lacro RV, Johnson KA, Adams JA. Pattern of malformations in the    children of women treated with carbamazepine during pregnancy. N Engl J Med    1991;321:674-7. </P>     <P>7 - Beghi E, Annegers J. for the Collaborative Group for the Pregnancy Registries    in Epilepsy. Epilepsia 2001;42:1422-25.</P>     <P>8 - Oguni M, Osawa M. Epilepsy and pregnancy. Epilepsia 2004;45:37-41.</P>     <P>9 - Kaplan PW. Reproductive health effects and teratogenicity of antiepileptic    drugs. Neurology 2004;63:13-23. </P>     <P>10 - Tomson T, Peruca E, Battino D. Navigating toward fetal and maternal health:    the challenge of trating epilepsy in pregnancy. Epilepsia 2004;45:1171-5. </P>     <P>11 - Sabers A, Dam M, A-Rogvi-Hansen B, et al. Epilepsy and pregnancy: lamotrigine    as main drug used. Acta Neurol Scand 2004;109:9-13. </P>     <P>12 - Cunnington MC. The international lamotrigine pregnancy registry update    for the epilepsy foundation. Epilepsia 2004;45:1468. </P>     ]]></body>
<body><![CDATA[<P>13 - Pennell PB. The importance of monotherapy in pregnancy. Neurology 2003;60(11    suppl 4):S31-8. </P>     <P>14 - Report of the Quality Standarts Subcommittee of the American Academy of    Neurology. Practice parameter: management issues for women with epilepsy (summary    statement). Neurology 1998;51:944-8. </P>     <P>15 - Pschirrer E, Monga M. Seizure disorders in pregnancy. Obstet Gynecol Clin    2001;28:601-11. </P>     <P>16 - Richard A, Bronsteen MD, Christine H, et al. Central Nervous System Anomalies.    Clin in Perinatol 2000; 27: 791812. </P>     <P>17 - Malone F, Dalton M. Drugs in pregnancy: anticonvulsivants. Semin Perinatol    1997; 21:114-23.</P>     <P>18 - Lynn L, Simpson MD. Structural Cardiac Anomalies. . Clin in Perinatol    2000; 27: 839-63. </P>     <P>19 - Adab N, Tudur SC, Vinten J, Willianson P, Winterbotton J. Common antiepileptic    drugs in pregnancy in women with epilepsy. Cochrane Database Rev 2004;CD004848.  </P>      <P>&nbsp;</P>      <P align="right"><B>Correspondência: </B></P>     <P align="right">Dr.ª Carla Tovim Rodrigues</P>     ]]></body>
<body><![CDATA[<P align="right">Serviço de Obstetrícia</P>     <P align="right">Maternidade Bissaya-Barreto</P>     <P align="right">Rua Augusta 3000 Coimbra </P>     <P align="right">e-mail: <a href="mailto:carlatr1@hotmail.com">carlatr1@hotmail.com</a>  </P>      ]]></body><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kilpatrick]]></surname>
<given-names><![CDATA[CJ]]></given-names>
</name>
<name>
<surname><![CDATA[Hopper]]></surname>
<given-names><![CDATA[JL.]]></given-names>
</name>
</person-group>
<article-title xml:lang="pt"><![CDATA[O efeito exercido pela gravidez sobre a epilepsia, segundo um estudo de 37 gravidezes.]]></article-title>
<source><![CDATA[Revista de Obstetrícia e Ginecologia]]></source>
<year>1994</year>
<volume>17</volume>
<page-range>373-5</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
