Apresentação de Um Caso Clínico e Revisão da Literatura

Anabela Silva; Ana Costa; Estela Ramos

Serviço de Medicina Interna, Hospital Pedro Hispano, Matosinhos

Os autores apresentam um caso de trombocitopenia grave de causa presumivelmente imune numa jovem do sexo feminino que tinha sido previamente medicada com griseofulvina para tratamento de lesões cutâneas. O estudo revelou apresentar uma Sarcoidose estadio II. Discutem ainda a relação etiopatogénica entre ambas as doenças e as implicações terapêuticas.

Palavras-chave: Sarcoidose; Trombocitopenia; Griseofulvina

The authors present a case of severe most probably immune-mediated thrombocytopenia in a young female that had been medicated with griseofulvin for cutaneous lesions, whose diagnosis was stage II Sarcoidosis. They also discuss the etiopathogenic relationship between both conditions, as well as the therapeutic implications.

Key-words: Sarcoidosis; Thrombocytopenia; Griseofulvin.

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REFERÊNCIAS

1- Newman LS, Rose CS, Maier LA: Sarcoidosis. N Engl J Med 1997; 336:1224-34.        [ Links ]

2 - Joint Statement of the American Thoracic Society, the European Respiratory Society and the World Association of Sarcoidosis and Other Granulomatous Disorders adopted by the ATS Board of Directors and the ERS Executives Committee, February, 1999: Statement on Sarcoidosis. Am J Respir and Critical Care Med 1999;160:736-55.

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7 - Chakrabarti S, Behera D, Varma S, et al: High-dose methylprednisolone for autoimmune thrombocytopenia in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 1997;14:188.

8 - Viallard JF, Parrens M, Hermine O, et al: Severe prolonged red blood cell aplasia and thrombocytopenia induced by parvovirus B19 infection in a patient with sarcoidosis. Clin Infect Dis 2003;36:229-33.

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Correspondência:

Dr.ª Anabela Silva

Hospital Pedro Hispano

Rua Dr. Eduardo Torres

4450 Matosinhos

e-mail: anabeladoc@yahoo.com