Bárbara Peleteiro
Serviço de Higiene e Epidemiologia, Faculdade de Medicina da Universidade do Porto
Abstract
The infection with Helicobacter pylori affects more than 50% of the world adult population, and approximately two thirds of all cases of stomach cancer are attributed to it, but a large proportion of the infected subjects will never develop cancer. Gastric carcinogenesis is currently interpreted as a multifactorial and multistage process, with environmental exposures (H. pylori infection and behavioural factors), and genetic susceptibility contributing for the occurrence of cancer. The study of the risk factors for precancerous lesions is a major field of research with potential to clarify the aetiology of gastric cancer, namely through the understanding of the mechanisms that modulate the progression to cancer among the infected.
Key-words: gastric cancer; precancerous lesions; intestinal metaplasia; Helicobacter pylori; risk factors
Resumo
Factores de Risco para o Desenvolvimento de Metaplasia Intestinal da Mucosa Gástrica
]]> A infecção por Helicobacter pylori afecta mais de 50% da população adulta mundial, à qual são atribuídos cerca de dois terços de todos os casos de cancro, mas apenas uma pequena proporção de indivíduos infectados desenvolve a doença. Actualmente, a carcinogénese gástrica é interpretada como um processo multifactorial em que exposições ambientais (infecção por H. pylori e factores comportamentais) e a susceptibilidade genética contribuem para a ocorrência de cancro. O estudo dos factores de risco para as lesões pré-cancerosas é um importante campo de investigação com potencial para melhorar o conhecimento acerca da etologia do cancro do estômago e possibilitar o desenvolvimento de estratégias de prevenção.Palavras-chave: cancro do estômago; lesões pré-cancerosas; metaplasia intestinal; Helicobacter pylori; factores de risco
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Correspondência:
Drª Bárbara Peleteiro Serviço de Higiene e Epidemiologia Faculdade de Medicina da Universidade do Porto
Alameda Prof. Hernâni Monteiro 4200-319 Porto
]]> e-mail: barbarap@med.up.pt]]>