<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0871-9721</journal-id>
<journal-title><![CDATA[Revista Portuguesa de Imunoalergologia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Port Imunoalergologia]]></abbrev-journal-title>
<issn>0871-9721</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Alergologia e Imunologia Clínica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0871-97212021000100049</article-id>
<article-id pub-id-type="doi">10.32932/rpia.2021.03.053</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Síndrome alfa-gal: Dois casos clínicos]]></article-title>
<article-title xml:lang="en"><![CDATA[Alpha-gal syndrome: Two case reports]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernandes]]></surname>
<given-names><![CDATA[Mara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sousa]]></surname>
<given-names><![CDATA[Filipa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Câmara]]></surname>
<given-names><![CDATA[Rita]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Doutor Nélio Mendonça Unidade de Imunoalergologia ]]></institution>
<addr-line><![CDATA[Funchal ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2021</year>
</pub-date>
<volume>29</volume>
<numero>1</numero>
<fpage>49</fpage>
<lpage>53</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0871-97212021000100049&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0871-97212021000100049&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0871-97212021000100049&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO  Introdução: Os casos descritos de alergia a carnes vermelhas têm vindo a aumentar e estão relacionados com a sensibilização à galactose&#8209;&#945;&#8209;1,3 galactose (alfa&#8209;gal).  Casos clínicos: Os autores descrevem dois casos de alergia a carnes vermelhas por sensibilização a alfa&#8209;gal. Caso A: Sexo masculino, 47 anos, antecedentes de atopia, com vários episódios de urticária generalizada e angioedema do lábio entre 30 minutos a 6 horas após ingestão de carnes vermelhas. Os testes cutâneos foram positivos para carnes vermelhas e as IgE específicas positivas para carne de porco, vaca e alfa&#8209;gal. Caso B: Sexo masculino, 42 anos, sem antecedentes de atopia, com urticária generalizada e sensação de edema da orofaringe 6 horas após ingestão de carne de porco (&gt; 10 episódios). Os testes cutâneos foram positivos para carne de porco e as IgE específicas positivas para carne de porco, vaca e alfa&#8209;gal. Após evicção de carnes vermelhas nenhum doente voltou a apresentar sintomas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Background: Hypersensitivity to red meat has been increasing and is related to sensitization to galactose&#8209;&#945;&#8209;1, 3&#8209;galactose (alpha&#8209;gal).  Case reports: The authors describe 2 cases of red meat allergy due to alpha&#8209;gal sensitization. Case A: 47&#8209;year&#8209;old atopic male, with several episodes of generalized urticaria and lip angioedema, 30 minutes to 6 hours after ingestion of red meat. Skin tests were positive to red meat and specific IgE positive for pork, beef and alpha&#8209;gal. Case B: 42&#8209;year old male without any atopic disease, with generalized urticaria and oropharyngeal tightening 6h after pork ingestion (&gt; 10 episodes). Skin tests were positive to pork and specific IgE assay positive for pork, beef and alpha&#8209;gal. After red meat avoidance, no other manifestations were reported.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Alergia alimentar]]></kwd>
<kwd lng="pt"><![CDATA[alfa&#8209;gal]]></kwd>
<kwd lng="pt"><![CDATA[carnes vermelhas]]></kwd>
<kwd lng="en"><![CDATA[Alpha&#8209;gal]]></kwd>
<kwd lng="en"><![CDATA[food allergy]]></kwd>
<kwd lng="en"><![CDATA[red meat.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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