<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0871-9721</journal-id>
<journal-title><![CDATA[Revista Portuguesa de Imunoalergologia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Port Imunoalergologia]]></abbrev-journal-title>
<issn>0871-9721</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Alergologia e Imunologia Clínica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0871-97212021000200095</article-id>
<article-id pub-id-type="doi">10.32932/rpia.2021.07.057</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Rinite alérgica - Classificação, fisiopatologia, diagnóstico e tratamento]]></article-title>
<article-title xml:lang="en"><![CDATA[Allergic rhinitis - Classification, pathophysiology, diagnosis and treatment]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Caldeira]]></surname>
<given-names><![CDATA[Leonor Esteves]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[Maria Inês T.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martins-dos-Santos]]></surname>
<given-names><![CDATA[Gonçalo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pereira]]></surname>
<given-names><![CDATA[Ana Margarida]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A5"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Hospitalar Universitário Lisboa Norte EPE Hospital Santa Maria Serviço de Imunoalergologia]]></institution>
<addr-line><![CDATA[Lisboa ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Hospitalar Universitário de Lisboa Central Serviço de Imunoalergologia ]]></institution>
<addr-line><![CDATA[Lisboa ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,CUF-Porto Instituto e Hospital  ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidade do Porto Faculdade de Medicina MEDCIDS - Departamento Medicina da Comunidade]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidade do Porto Faculdade de Medicina CINTESIS - Center for Health Technology and Services Research]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>06</month>
<year>2021</year>
</pub-date>
<volume>29</volume>
<numero>2</numero>
<fpage>95</fpage>
<lpage>106</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0871-97212021000200095&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0871-97212021000200095&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0871-97212021000200095&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO A rinite alérgica é uma patologia inflamatória da mucosa nasal, mediada por imunoglobulina E (IgE), que se manifesta por rinorreia mucosa, obstrução nasal, crises esternutatórias e/ou prurido nasal em relação com a exposição a aeroalergénios. A sua classificação depende da duração e gravidade dos sintomas que, quando não controlados, podem apresentar um grande impacto na qualidade de vida. Embora de diagnóstico essencialmente clínico, o recurso a testes cutâneos por picada e doseamento sérico de IgE específicas é importante na confirmação da etiologia e na caraterização dos alergénios envolvidos. O tratamento baseia&#8209;se em medidas de controlo ambiental, em terapêutica farmacológica e, em casos selecionados, no uso da imunoterapia com alergénios. Este artigo tem como objetivo reunir a atual evidência científica relativa à rinite alérgica, no que se refere à sua fisiopatologia, diagnóstico e adequada abordagem terapêutica, usando um caso clínico para contextualização do problema.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Allergic rhinitis is an immunoglobulin E (IgE)&#8209;mediated inflammatory pathology of the nasal mucosa clinically characterized by mucous rhinorrhea, nasal congestion, sneezing and/or nasal itch. Its classification depends on the duration and severity of symptoms which, when not controlled, can have a major impact on quality of life. Although the diagnosis is mainly based on clinical features, the use of skin prick testing and allergen&#8209;specific serum IgE measurements are important to confirm the etiology and characterize the involved allergens. Treatment includes environmental control measures, pharmacological treatment and, in selected cases, allergen immunotherapy. The aim of this article is to gather current scientific evidence on allergic rhinitis, in what concerns its pathophysiology, diagnosis and appropriate management, using a clinical vignette as a starting point.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Hipersensibilidade imediata]]></kwd>
<kwd lng="pt"><![CDATA[imunoterapia com alergénios]]></kwd>
<kwd lng="pt"><![CDATA[medicina de precisão]]></kwd>
<kwd lng="pt"><![CDATA[rinite alérgica.]]></kwd>
<kwd lng="en"><![CDATA[Allergic rhinitis]]></kwd>
<kwd lng="en"><![CDATA[immediate hypersensitivity]]></kwd>
<kwd lng="en"><![CDATA[allergen immunotherapy]]></kwd>
<kwd lng="en"><![CDATA[precision medicine.]]></kwd>
</kwd-group>
</article-meta>
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