<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0871-9721</journal-id>
<journal-title><![CDATA[Revista Portuguesa de Imunoalergologia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Port Imunoalergologia]]></abbrev-journal-title>
<issn>0871-9721</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Alergologia e Imunologia Clínica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0871-97212021000300167</article-id>
<article-id pub-id-type="doi">10.32932/rpia.2021.09.063</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Segurança do protocolo ultra-rush na imunoterapia a venenos de himenópteros: Avaliação de fatores de risco para reações adversas]]></article-title>
<article-title xml:lang="en"><![CDATA[Safety of ultra-rush protocol on venom immunotherapy: Evaluation of risk factors for adverse events]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lopes]]></surname>
<given-names><![CDATA[Joana Barradas]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barreira]]></surname>
<given-names><![CDATA[Patrícia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santa]]></surname>
<given-names><![CDATA[Cátia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[Cristiana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mesquita]]></surname>
<given-names><![CDATA[Márcio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[José Pedro Moreira da]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lopes]]></surname>
<given-names><![CDATA[Inês]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Hospitalar de Vila Nova de Gaia/ Espinho Serviço de Imunoalergologia ]]></institution>
<addr-line><![CDATA[Vila de Nova de Gaia ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>09</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>09</month>
<year>2021</year>
</pub-date>
<volume>29</volume>
<numero>3</numero>
<fpage>167</fpage>
<lpage>178</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0871-97212021000300167&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0871-97212021000300167&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0871-97212021000300167&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO  Fundamentos: A imunoterapia a veneno de himenópteros (VIT) é eficaz na prevenção de reações graves a picadas destes insetos. Existem diferentes protocolos, sendo os ultra-rush (UR) os mais rápidos. No entanto, permanecem dúvidas sobre a sua segurança e fatores de risco envolvidos em reações adversas (RA).  Objetivo: Avaliar a segurança e fatores de risco para RA a VIT segundo protocolo UR.  Métodos: Análise retrospetiva de doentes tratados com VIT segundo protocolo UR para abelha, vespa, polistes (2010-2019). Foram avaliadas a segurança e os fatores de risco para RA.  Resultados: Incluídos 82 doentes: 77% homens, mediana de idade de 46 anos (8-76). Na fase de iniciação, RA sistémicas ocorreram em 13% dos doentes (n=11), em 91% com VIT a abelha. As RA sistémicas foram em 36% ligeiras, 64% moderadas. Em 3 destes doentes foi iniciado pré-tratamento com omalizumab, com posterior tolerância da pauta. RA locais exuberantes ocorreram em 17%. Houve associação entre VIT a abelha e ocorrência de RA sistémicas (p=0,003). Os níveis de IgE para abelha foram significativamente mais elevados no grupo dos doentes com RA sistémicas (p=0,027). Não houve associação com o género, reação inicial à picada, atopia, uso de IECA ou &#946;-bloqueadores. Não houve diferença estatisticamente significativa com idade, IgE total, restantes IgE específicas, triptase basal ou concentração de positividade dos testes cutâneos.  Conclusão: As RA sistémicas na iniciação foram sobretudo locais e/ou sistémicas ligeiras/moderadas, com boa resposta ao tratamento instituído. O pré-tratamento com omalizumab foi eficaz nos doentes com RA sistémicas de maior gravidade, permitindo que a dose de manutenção fosse tolerada, sem intercorrências de relevo. A VIT de abelha e níveis mais elevados de IgE específica a abelha correlacionaram-se com RA sistémicas. Na sua presença sugere-se ponderação do risco, com eventual pré-tratamento com omalizumab.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Background: Hymenoptera venom immunotherapy (VIT) is effective in preventing severe reactions to insect bites. Different protocols exist, being ultra-rush (UR) the fastest. However, doubts remain about its safety and risk factors involved in adverse reactions (AR).  Objective: To evaluate the safety and risk factors for AR to VIT using the UR protocol.  Methods:  Retrospective analysis of patients treated with VIT according to UR protocol for bee, wasp, polistes (2010-2019). Safety and risk factors for AR were assessed.  Results: Eighty-two patients were included: 77% men, median age 46 years (8-76). During the build-up phase, systemic AR occurred in 13% of patients (n = 11), 91% with VIT to bee. Systemic AR were mild in 36%, moderate in 64%. In 3 of these patients, pretreatment with Omalizumab was started, with subsequente tolerance of the protocol. Large local AR occurred in 17% of patients. There was an association between VIT to bee and the occurrence of systemic AR (p=0.003). Specific IgE to bee was significantly higher in the group of patients with systemic AR (p=0.027). There was no association with sex, initial reaction to the bite, atopy, use of ACE inhibitors or &#946;-blockers. There was no statistically significant difference with age, total IgE, other specific IgE, basal tryptase, or concentration of the positive skin tests.  Conclusion: Systemic AR during the build-up phase were mainly local and/or systemic mild / moderate, with good response to the treatment instituted. Pretreatment with Omalizumab was effective in patients with severe systemic AR, allowing the maintenance dose to be tolerated, without major complications. VIT to bee and higher levels of bee specific IgE are related to systemic RA. In these contexts, the risk should be weighted, and pre-treatment with Omalizumab may be considered.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Alergia]]></kwd>
<kwd lng="pt"><![CDATA[himenópteros]]></kwd>
<kwd lng="pt"><![CDATA[imunoterapia]]></kwd>
<kwd lng="pt"><![CDATA[reações adversas]]></kwd>
<kwd lng="pt"><![CDATA[ultra-rush]]></kwd>
<kwd lng="pt"><![CDATA[venenos.]]></kwd>
<kwd lng="en"><![CDATA[Adverse reactions]]></kwd>
<kwd lng="en"><![CDATA[allergy]]></kwd>
<kwd lng="en"><![CDATA[hymenoptera]]></kwd>
<kwd lng="en"><![CDATA[immunotherapy]]></kwd>
<kwd lng="en"><![CDATA[ultra-rush]]></kwd>
<kwd lng="en"><![CDATA[venom.]]></kwd>
</kwd-group>
</article-meta>
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