<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0871-9721</journal-id>
<journal-title><![CDATA[Revista Portuguesa de Imunoalergologia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Port Imunoalergologia]]></abbrev-journal-title>
<issn>0871-9721</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Alergologia e Imunologia Clínica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0871-97212022000300207</article-id>
<article-id pub-id-type="doi">10.32932/rpia.2022.09.088</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Rinossinusite crónica com e sem polipose nasal]]></article-title>
<article-title xml:lang="en"><![CDATA[Chronic rhinosinusitis with and without nasal polyposis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santa]]></surname>
<given-names><![CDATA[Cátia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[Cristiana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sangalho]]></surname>
<given-names><![CDATA[Inês]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Coutinho]]></surname>
<given-names><![CDATA[Iolanda Alen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gouveia]]></surname>
<given-names><![CDATA[Joana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carvalho]]></surname>
<given-names><![CDATA[Jóni Costa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mesquita]]></surname>
<given-names><![CDATA[Márcio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Brás]]></surname>
<given-names><![CDATA[Rita]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rama]]></surname>
<given-names><![CDATA[Tiago]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pereira]]></surname>
<given-names><![CDATA[Ana Margarida]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A10"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Hospitalar de Vila Nova de Gaia/ Espinho Serviço de Imunoalergologia ]]></institution>
<addr-line><![CDATA[Vila Nova de Gaia ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Hospitalar Universitário de Lisboa Central Hospital de Dona Estefânia Serviço de Imunoalergologia]]></institution>
<addr-line><![CDATA[Lisboa ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Centro Hospitalar e Universitário de Coimbra Hospitais da Universidade de Coimbra Serviço de Imunoalergologia]]></institution>
<addr-line><![CDATA[Coimbra ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Centro Hospitalar Universitário do Porto  ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Centro Hospitalar Lisboa Norte Hospital de Santa Maria Serviço de Imunoalergologia]]></institution>
<addr-line><![CDATA[Lisboa ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Centro Hospitalar Universitário de São João Serviço de Imunoalergologia ]]></institution>
<addr-line><![CDATA[Lisboa ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af7">
<institution><![CDATA[,Faculdade de Medicina da Universidade do Porto Serviço de Imunologia, Departamento de Patologia ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af8">
<institution><![CDATA[,Hospital CUF Porto e Instituto CUF Porto Unidade de Imunoalergologia ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af9">
<institution><![CDATA[,Faculdade de Medicina da Universidade do Porto Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS) ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="A10">
<institution><![CDATA[,Faculdade de Medicina da Universidade do Porto Departamento Medicina da Comunidade, Informação e Decisão em Saúde (MEDCIDS) ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>09</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>09</month>
<year>2022</year>
</pub-date>
<volume>30</volume>
<numero>3</numero>
<fpage>207</fpage>
<lpage>221</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0871-97212022000300207&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0871-97212022000300207&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0871-97212022000300207&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO A rinossinusite crónica, considerada atualmente um problema de saúde pública, é um grupo heterogéneo de doenças com etiologia multifatorial e caracteriza&#8209;se pela presença de sintomas nasossinusais caraterísticos, em associação com evidência clínica ou imagiológica de inflamação. Pode ser subdividida em rinossinusite crónica sem polipose nasal (RSCsPN) e em rinossinusite crónica com polipose nasal (RSCcPN), existindo várias patologias que podem ser consideradas subfenótipos adicionais da rinossinusite crónica. É também importante ter em conta as principais patologias que devem ser consideradas no seu diagnóstico diferencial. O tratamento médico de eleição é dirigido à inflamação nasossinusal, sendo o tratamento cirúrgico necessário nos doentes refratários ao tratamento médico ou com contraindicação à realização do mesmo. Este artigo tem por objetivo rever a informação disponível na literatura sobre a rinossinusite crónica, tendo como ponto de partida um caso clínico de um doente com RSCcPN seguido em consulta de Imunoalergologia.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Chronic rhinosinusitis, currently considered a public health problem, is a heterogeneous group of entities with a multifactorial etiology and is characterized by the presence of characteristic nasosinusal symptoms in association with clinical or radiographic features of inflammation. It can be subdivided into chronic rhinosinusitis without nasal polyps (CRSsNP) and chronic rhinosinusitis with nasal polyps (CRSwNP), with several variants that can be considered as additional chronic rhinosinusitis subphenotypes. It is also important to take into consideration its main differential diagnosis. The preferred medical treatment should be directed towards nasosinusal inflammation. Surgical treatment might be necessary in patients who are refractory or present contraindications to medical treatment. This paper aims to review the literature on chronic rhinosinusitis presenting a clinical vignette of a patient with CRSwNP followed in an Allergy and Clinical Immunology Department as a starting point.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Polipose nasal]]></kwd>
<kwd lng="pt"><![CDATA[rinite]]></kwd>
<kwd lng="pt"><![CDATA[rinossinusite]]></kwd>
<kwd lng="en"><![CDATA[Nasal polyposis]]></kwd>
<kwd lng="en"><![CDATA[rhinitis]]></kwd>
<kwd lng="en"><![CDATA[rhinosinusitis]]></kwd>
</kwd-group>
</article-meta>
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