<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0871-9721</journal-id>
<journal-title><![CDATA[Revista Portuguesa de Imunoalergologia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Port Imunoalergologia]]></abbrev-journal-title>
<issn>0871-9721</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Alergologia e Imunologia Clínica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0871-97212025000100027</article-id>
<article-id pub-id-type="doi">10.32932/rpia.2025.03.154</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Rinossinusite crónica e imunodeficiências primárias - Uma relação menosprezada]]></article-title>
<article-title xml:lang="en"><![CDATA[Chronic rhinosinusitis and primary immunodeficiencies - An underestimated relationship]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Farinha]]></surname>
<given-names><![CDATA[Inês]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Freitas]]></surname>
<given-names><![CDATA[Tomás]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Faria]]></surname>
<given-names><![CDATA[Emília]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Loureiro]]></surname>
<given-names><![CDATA[Graça]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Unidade Local de Saúde de Coimbra Serviço de Imunoalergologia ]]></institution>
<addr-line><![CDATA[Coimbra ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Grupo de Interesse de Imunodeficiências Primárias da SPAIC  ]]></institution>
<addr-line><![CDATA[Lisboa ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Grupo de Interesse de Rinite/Rinossinusite da SPAIC  ]]></institution>
<addr-line><![CDATA[Lisboa ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2025</year>
</pub-date>
<volume>33</volume>
<numero>1</numero>
<fpage>27</fpage>
<lpage>37</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0871-97212025000100027&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0871-97212025000100027&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0871-97212025000100027&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO As imunodeficiências primárias (IDP), mais recentemente designadas erros inatos da imunidade, compreendem um grande grupo de doenças heterogéneas, na sua globalidade associadas a um aumento da incidência de infeções, autoimunidade, doenças autoinflamatórias, alergias e neoplasias. A rinossinusite crónica (RSC) representa uma das complicações mais frequentes nestes doentes, destacando-se que episódios recorrentes e graves de sinusite são um dos 10 sinais de alerta de IDP propostos pela Fundação Jeffrey Modell. As deficiências predominantemente de anticorpos são as IDP mais frequentemente associadas à RSC. O reconhecimento e diagnóstico precoce de IDP em indivíduos com RSC possibilita o tratamento precoce das agudizações e, se indicado, considerar antibioterapia profilática e reposição de imunoglobulina humana. Uma abordagem multidisciplinar e de cooperação entre especialistas em imunoalergologia e otorrinolaringologia, é fundamental para o correto enquadramento diagnóstico e terapêutico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Primary Immunodeficiencies (PID), more recently referred to as Inborn Errors of Immunity, comprise a large and heterogenous group of diseases globally associated with an increased incidence of infections, autoimmunity, auto-inflammatory diseases, allergies, and cancer. Chronic rhinosinusitis (CRS) is one of the most frequent complications in these patients, and recurrent, severe episodes of sinusitis are among the 10 warning signs of PID proposed by the Jeffrey Modell Foundation. Predominantly antibody deficiencies are the PIDs most frequently associated with CRS. Early recognition and diagnosis of PIDs in individuals with CRS enables early treatment of exacerbations and, if indicated, consideration of prophylactic antibiotic therapy and human immunoglobulin replacement. A multidisciplinary approach and cooperation between specialists in immuno-allergology and otorhinolaryngology is essential for the correct diagnosis and treatment.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Erros inatos da imunidade]]></kwd>
<kwd lng="pt"><![CDATA[imunodeficiências primárias]]></kwd>
<kwd lng="pt"><![CDATA[rinossinusite crónica]]></kwd>
<kwd lng="en"><![CDATA[Chronic rhinosinusitis]]></kwd>
<kwd lng="en"><![CDATA[inborn errors of immunity]]></kwd>
<kwd lng="en"><![CDATA[primary immunodeficiencies]]></kwd>
</kwd-group>
</article-meta>
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