<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0871-9721</journal-id>
<journal-title><![CDATA[Revista Portuguesa de Imunoalergologia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Port Imunoalergologia]]></abbrev-journal-title>
<issn>0871-9721</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Alergologia e Imunologia Clínica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0871-97212025000200091</article-id>
<article-id pub-id-type="doi">10.32932/rpia.2025.03.157</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Tosse crónica]]></article-title>
<article-title xml:lang="en"><![CDATA[Chronic cough]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bragança]]></surname>
<given-names><![CDATA[Mariana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vasconcelos]]></surname>
<given-names><![CDATA[Maria João]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Amaral]]></surname>
<given-names><![CDATA[Luís]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Unidade Local de Saúde de São João Serviço de Imunoalergologia ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Lusíadas Porto Unidade de Imunoalergologia ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<volume>33</volume>
<numero>2</numero>
<fpage>91</fpage>
<lpage>105</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0871-97212025000200091&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0871-97212025000200091&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0871-97212025000200091&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO A tosse é um sintoma prevalente e com um elevado impacto psicossocial e socioeconómico. Os mecanismos fisiopatológicos subjacentes são complexos e multiorgânicos. As principais causas incluem a síndrome das vias aéreas superiores, a asma, o refluxo gastroesofágico e a bronquite eosinofílica não asmática; no entanto, a tosse crónica pode resultar de muitas outras condições. Uma abordagem sistematizada e sequencial, com base numa história clínica e num exame físico detalhados é fundamental na gestão destes doentes. O tratamento deve ser dirigido à(s) causa(s) subjacente(s). Na tosse crónica idiopática, a estratégia terapêutica não é consensual, mas avanços recentes, como os antagonistas dos recetores P2X3, oferecem perspetivas promissoras para o futuro.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Cough is a prevalent symptom with a significant psychosocial and socioeconomic burden. The underlying pathophysiological mechanisms are complex and involve multiple organs. While common causes include upper airway syndrome, asthma, gastroesophageal reflux, and non-asthmatic eosinophilic bronchitis, chronic cough can derive from various other conditions. A systematic and sequential approach, based on comprehensive medical history and physical examination, is crucial in managing these patients. Treatment should target the underlying cause(s). In the case of idiopathic chronic cough, therapeutic strategies lack consensus, but recent advances, such as P2X3 receptor antagonists, show promising prospects for the future.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Tosse crónica]]></kwd>
<kwd lng="pt"><![CDATA[vias aéreas]]></kwd>
<kwd lng="pt"><![CDATA[fisiopatologia]]></kwd>
<kwd lng="pt"><![CDATA[diagnóstico,tratamento]]></kwd>
<kwd lng="en"><![CDATA[Chronic cough]]></kwd>
<kwd lng="en"><![CDATA[airway]]></kwd>
<kwd lng="en"><![CDATA[pathophysiology]]></kwd>
<kwd lng="en"><![CDATA[diagnosis]]></kwd>
<kwd lng="en"><![CDATA[treatment]]></kwd>
</kwd-group>
</article-meta>
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