<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0871-9721</journal-id>
<journal-title><![CDATA[Revista Portuguesa de Imunoalergologia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Port Imunoalergologia]]></abbrev-journal-title>
<issn>0871-9721</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Alergologia e Imunologia Clínica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0871-97212025000300183</article-id>
<article-id pub-id-type="doi">10.32932/rpia.2025.06.163</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Caracterização clínica e laboratorial de doentes com rinite alérgica sensibilizados a Der p 23]]></article-title>
<article-title xml:lang="en"><![CDATA[Clinical and laboratory characterization of patients with allergic rhinitis sensitized to Der p 23]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garcia]]></surname>
<given-names><![CDATA[Sonia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Unidade de Saúde Local Gaia e Espinho Serviço de Imunoalergologia ]]></institution>
<addr-line><![CDATA[Vila Nova de Gaia ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2025</year>
</pub-date>
<volume>33</volume>
<numero>3</numero>
<fpage>183</fpage>
<lpage>189</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0871-97212025000300183&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0871-97212025000300183&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0871-97212025000300183&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO  Introdução:  A sensibilização a ácaros do pó afeta uma elevada percentagem da população mundial, tendo impacto clínico e económico. A sensibilização a Der p 23 tem sido associada a rinite mais sintomática e a maior gravidade da asma.  Objetivo:  Neste trabalho pretende-se caracterizar doentes com rinite alérgica sensibilizados a Der p 23.  Métodos:  Incluíram-se doentes com rinite alérgica (associada ou não a asma) sensibilizados a Der p 23 entre dezembro de 2020 e janeiro de 2023. Foram utilizadas IgE total, IgE específicas para Dermatophagoides pteronyssinus (Dp) e Dermatophagoides farinae (Df) e os moleculares, Der p 1, Der p 2, Der p 10, e Der p 23. Na análise estatística, compararam-se os valores analíticos de acordo com a gravidade da rinite, com presença concomitante de asma e com o controlo da asma.  Resultados:  Foram incluídos 66 doentes, 53% do sexo feminino, com idade mediana de 23,7 anos (P25-P75: 3-52). Sessenta e um por cento dos participantes apresentavam rinite moderada-grave e 71% asma ligeira (dos 40 (61%) com asma). Na população estudada, 80% apresentavam sensibilização a Der p 1, 75% a Der p 2 e 19% a Der p 10. Seis doentes (9%) estavam monossensibilizados a Der p 23. Os valores de IgE para Der p 1, Der p 2 e Der p 23 foram significativamente superiores no grupo de doentes com rinite moderada-grave versus rinite ligeira. Os valores de IgE total, IgE Dp, IgE Df, Der p 2 e Der p 23 foram significativamente superiores na rinite associada a asma versus rinite isolada. Valores mais elevados de IgE total, IgE Dp e IgE Df associaram-se a maior frequência de asma não controlada.  Conclusão:  Nos doentes com rinite alérgica sensibilizados a Der p 23, os níveis elevados de Der p 1, Der p 2, e Der p 23 associaram-se a fenótipos mais graves de rinite alérgica, devendo estes parâmetros ser considerados na avaliação destes doentes. Menos de 10% destes doentes eram monossensibiizados a Der p 23. Os valores mais elevados de IgE total e específicas para Dp e Df são relevantes na associação com a presença de asma e com o seu não controlo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Background:  Sensitization to dust mites affects a high percentage of the world population, with clinical and economic impact. Sensitization to Der p 23 has been associated with more symptomatic rhinitis and higher asthma severity.  Objective:  This work intends to characterize patients with allergic rhinitis who are sensitized to Der p 23.  Methods:  Patients with allergic rhinitis (associated or not with asthma) sensitized to Der p 23 were included between December 2020 and January 2023. Total IgE, specific IgE to Dermatophagoides pteronyssinus (Dp) and Dermatophagoides farinae (Df), and the molecular allergens Der p 1, Der p 2, Der p 10, and Der p 23 were determined. In the statistical analysis, analytical results were compared according to the severity of rhinitis, the presence of concomitant asthma, and asthma control.  Results:  Sixty-six patients were included, 53% female, with a median age 23,7 years, IQR (3-52). Sixty-one percent of the participants had moderate&#8209;severe rhinitis, and 71% had mild asthma (out of 40(61%) with asthma). In the studied population, 80% were sensitized to Der p 1, 75% to Der p 2, and 19% to Der p 10; six patients (9%) were monosensitized to Der p 23. The values of IgE to Der p 1, Der p 2, and Der p 23 were significantly higher in the group of patients with moderate-severe rhinitis versus mild rhinitis. Total IgE, IgE to Dp, Df, Der p 2, and Der p 23 were significantly higher in rhinitis associated with asthma versus isolated rhinitis. Higher values of total IgE, IgE to Dp, and IgE to Df were associated with an increased frequency of uncontrolled asthma.  Conclusion: In patients with allergic rhinitis sensitized to Der p 23, high levels of Der p 1, Der p 2, and Der p 23 were associated with more severe allergic rhinitis phenotypes, underscoring the need to assess these parameters when evaluating these patients. Less than 10% of these patients were monosensitized to Der p 23. The higher values of total IgE and specific IgE to Dp and Df are relevant both in the association with the presence of asthma and its lack of control.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Ácaros]]></kwd>
<kwd lng="pt"><![CDATA[Der p 23]]></kwd>
<kwd lng="pt"><![CDATA[IgE específica]]></kwd>
<kwd lng="pt"><![CDATA[rinite alérgica]]></kwd>
<kwd lng="en"><![CDATA[House dust mites]]></kwd>
<kwd lng="en"><![CDATA[Der p 23]]></kwd>
<kwd lng="en"><![CDATA[Specific IgE]]></kwd>
<kwd lng="en"><![CDATA[allergic rhinitis]]></kwd>
</kwd-group>
</article-meta>
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<surname><![CDATA[Micarelli]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Nichelatti]]></surname>
<given-names><![CDATA[M]]></given-names>
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<article-title xml:lang=""><![CDATA[Mite-Induced asthma and IgE levels to shrimp, mite, tropomyosin, arginine kinase, and Der p 10 are the most relevant risk factors for challenge-proven shrimp allergy]]></article-title>
<source><![CDATA[Int Arch Allergy Immunol]]></source>
<year>2017</year>
<volume>174</volume>
<numero>3-4</numero>
<issue>3-4</issue>
<page-range>133-43</page-range></nlm-citation>
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</article>
