<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0872-0754</journal-id>
<journal-title><![CDATA[Nascer e Crescer]]></journal-title>
<abbrev-journal-title><![CDATA[Nascer e Crescer]]></abbrev-journal-title>
<issn>0872-0754</issn>
<publisher>
<publisher-name><![CDATA[Centro Hospitalar do Porto]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0872-07542021000200105</article-id>
<article-id pub-id-type="doi">10.25753/birthgrowthmj.v30.i2.18911</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Moebius syndrome - improving outcome with combined state-of-the-art surgical and rehabilitation treatments]]></article-title>
<article-title xml:lang="pt"><![CDATA[Síndrome de Moebius - melhorar o prognóstico com tratamentos cirúrgicos e de reabilitação de ponta]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castro]]></surname>
<given-names><![CDATA[João Paulo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vouga]]></surname>
<given-names><![CDATA[Luís Afonso]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jorge]]></surname>
<given-names><![CDATA[Inês Santos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cunha]]></surname>
<given-names><![CDATA[Maria Paz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Amorim]]></surname>
<given-names><![CDATA[Rosa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Palhau]]></surname>
<given-names><![CDATA[Lurdes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Hospitalar Vila Nova de Gaia/Espinho Department of Physical and Rehabilitation Medicine ]]></institution>
<addr-line><![CDATA[Vila Nova de Gaia ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Hospitalar Universitário do Porto Department of Physical and Rehabilitation Medicine ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidade do Porto Faculty of Medicine Unit of Anatomy, Department of Biomedicine]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Clínica Fisiátrica da Maia  ]]></institution>
<addr-line><![CDATA[Maia ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>06</month>
<year>2021</year>
</pub-date>
<volume>30</volume>
<numero>2</numero>
<fpage>105</fpage>
<lpage>108</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0872-07542021000200105&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0872-07542021000200105&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0872-07542021000200105&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Moebius Syndrome (MBS) is a rare disorder, characterized by congenital, non-progressive facial palsy and other cranial and limb defects. A typical &#8220;mask-like&#8221; appearance, drooling, and indistinct speech comprise the dominant features. Treatment focuses on correcting deformities and enhancing functionality. Surgical free functional muscle transfer (FFMT) is the gold standard for facial reanimation. A comprehensive rehabilitation program addressing motor, cognitive, and social impairment is paramount, despite the scarcity of knowledge regarding MBS rehabilitation, especially concerning central nervous system reorganization. A six-year-old boy with MBS received treatment in our Department since the age of four months, including speech, physical, and occupational therapy. Recently, he underwent facial reanimation surgery. The authors believe that rehabilitation improved the patient&#8217;s outcome by enhancing cortical representation before and neuroplasticity after surgery. Coordination of both interventions seems pivotal to fully address MBS.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo A síndrome de Moebius (MBS) é rara e caracteriza-se por paralisia facial e outros defeitos congénitos não-progressivos do crânio e membros. O fácies inexpressivo, a sialorreia abundante e o discurso ininteligível constituem as características dominantes. O tratamento visa corrigir deformidades e otimizar a função. A transferência de enxerto muscular funcional (FFMT) é o gold standard na cirurgia de reanimação facial. Um programa de reabilitação abrangente dirigido às limitações motoras, cognitivas e funcionais também é fundamental, apesar da escassez de conhecimento acerca da reabilitação na MBS, sobretudo no que diz respeito à reorganização do sistema nervoso central. Um rapaz de seis anos com MBS recebeu tratamento no nosso Departamento desde os quatro meses, incluindo terapia da fala, fisioterapia e terapia ocupacional. Recentemente, foi submetido a cirurgia de reanimação facial noutra instituição. Os autores acreditam que a reabilitação melhorou o resultado final, ao potenciar a representação cortical antes e a neuroplasticidade após a cirurgia. A coordenação entre ambas as intervenções parece essencial para o tratamento holístico do MBS.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[facial paralysis]]></kwd>
<kwd lng="en"><![CDATA[Moebius syndrome, occupational therapy, physiatry, physical therapy, rehabilitation, speech therapy]]></kwd>
<kwd lng="pt"><![CDATA[fisiatria]]></kwd>
<kwd lng="pt"><![CDATA[fisioterapia]]></kwd>
<kwd lng="pt"><![CDATA[paralisia facial]]></kwd>
<kwd lng="pt"><![CDATA[reabilitação]]></kwd>
<kwd lng="pt"><![CDATA[síndrome de Moebius]]></kwd>
<kwd lng="pt"><![CDATA[terapia da fala]]></kwd>
<kwd lng="pt"><![CDATA[terapia ocupacional]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Moebius syndrome]]></article-title>
<source><![CDATA[Journal of medical genetics]]></source>
<year>1990</year>
<volume>27</volume>
<page-range>122-6</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aguilera-Salgado]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Cardenas]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[One-stage facial reanimation with bilateral free gracilis muscle transfer in complete Möbius Syndrome]]></article-title>
<source><![CDATA[Cirugía Plastica Ibero-Latinoamericana]]></source>
<year>2018</year>
<volume>44</volume>
<page-range>75-83</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ferrari]]></surname>
<given-names><![CDATA[PF]]></given-names>
</name>
<name>
<surname><![CDATA[Barbot]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bianchi]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Ferri]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Garofalo]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Bruno]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A proposal for new neurorehabilitative intervention on Moebius Syndrome patients after 'smile surgery' Proof of concept based on mirror neuron system properties and hand-mouth synergistic activity]]></article-title>
<source><![CDATA[Neuroscience and Biobehavioral Reviews]]></source>
<year>2017</year>
<volume>76</volume>
<page-range>111-22</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Terzis]]></surname>
<given-names><![CDATA[JK]]></given-names>
</name>
<name>
<surname><![CDATA[Noah]]></surname>
<given-names><![CDATA[EM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mobius and Mobius-like patients etiology, diagnosis, and treatment options]]></article-title>
<source><![CDATA[Clinics in Plastic Surgery]]></source>
<year>2002</year>
<volume>29</volume>
<page-range>497-514</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[McKay]]></surname>
<given-names><![CDATA[VH]]></given-names>
</name>
<name>
<surname><![CDATA[Touil]]></surname>
<given-names><![CDATA[LL]]></given-names>
</name>
<name>
<surname><![CDATA[Jenkins]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Fattah]]></surname>
<given-names><![CDATA[AY]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Managing the child with a diagnosis of Moebius syndrome more than meets the eye]]></article-title>
<source><![CDATA[Archives of Disease in Childhood]]></source>
<year>2016</year>
<volume>101</volume>
<page-range>843-6</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Marre]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Hontanilla]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Brain plasticity in Mobius syndrome after unilateral muscle transfer case report and review of the literature]]></article-title>
<source><![CDATA[Annals of Plastic Surgery]]></source>
<year>2012</year>
<volume>68</volume>
<page-range>97-100</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chuang]]></surname>
<given-names><![CDATA[DC]]></given-names>
</name>
<name>
<surname><![CDATA[Lu]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[Chang]]></surname>
<given-names><![CDATA[TN]]></given-names>
</name>
<name>
<surname><![CDATA[Laurence]]></surname>
<given-names><![CDATA[VG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comparison of Functional Results After Cross-Face Nerve Graft-, Spinal Accessory Nerve-, and Masseter Nerve-Innervated Gracilis for Facial Paralysis Reconstruction The Chang Gung Experience]]></article-title>
<source><![CDATA[Annals of Plastic Surgery]]></source>
<year>2018</year>
<volume>81</volume>
<page-range>S21-S9</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rizzolatti]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Fogassi]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The mirror mechanism recent findings and perspectives]]></article-title>
<source><![CDATA[Philosophical transactions of the Royal Society of London Series B, Biological sciences]]></source>
<year>2014</year>
<volume>369</volume>
<page-range>20130420</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guimarães]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Birrento]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Figueiredo]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Flores]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<source><![CDATA[Teste de articulação verbal]]></source>
<year>2014</year>
</nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bosques]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Martin]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[McGee]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Sadowsky]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Does therapeutic electrical stimulation improve function in children with disabilities A comprehensive literature review]]></article-title>
<source><![CDATA[Journal of Pediatric Rehabilitation Medicine]]></source>
<year>2016</year>
<volume>9</volume>
<page-range>83-99</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Picciolini]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Porro]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Cattaneo]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Castelletti]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Masera]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Mosca]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Moebius syndrome clinical features, diagnosis, management and early intervention]]></article-title>
<source><![CDATA[Italian journal of Pediatrics]]></source>
<year>2016</year>
<volume>42</volume>
<page-range>56</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yla-Kotola]]></surname>
<given-names><![CDATA[TM]]></given-names>
</name>
<name>
<surname><![CDATA[Kauhanen]]></surname>
<given-names><![CDATA[MS]]></given-names>
</name>
<name>
<surname><![CDATA[Koskinen]]></surname>
<given-names><![CDATA[SK]]></given-names>
</name>
<name>
<surname><![CDATA[Asko-Seljavaara]]></surname>
<given-names><![CDATA[SL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Magnetic resonance imaging of microneurovascular free muscle flaps in facial reanimation]]></article-title>
<source><![CDATA[British Journal of Plastic Surgery]]></source>
<year>2005</year>
<volume>58</volume>
<page-range>22-7</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fairgray]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Miles]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Enhancing surgical outcomes The effects of speech therapy on a school-aged girl with Moebius Syndrome]]></article-title>
<source><![CDATA[International Journal of Pediatric Otorhinolaryngology]]></source>
<year>2016</year>
<volume>90</volume>
<page-range>58-62</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rodel]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
<name>
<surname><![CDATA[Tergau]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Markus]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Laskawi]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Bilateral changes in cortical motor representation of the tongue after unilateral peripheral facial paralysis evidence from transcranial magnetic stimulation]]></article-title>
<source><![CDATA[The Annals of Otology, Rhinology, and Laryngology]]></source>
<year>2004</year>
<volume>113</volume>
<page-range>951-5</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gallese]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Goldman]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mirror neurons and the simulation theory of mind-reading]]></article-title>
<source><![CDATA[Trends in Cognitive Sciences]]></source>
<year>1998</year>
<volume>2</volume>
<page-range>493-501</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Salles]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Girones]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Lafuente]]></surname>
<given-names><![CDATA[JV]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The motor organization of cerebral cortex and the role of the mirror neuron system Clinical impact for rehabilitation]]></article-title>
<source><![CDATA[Medicina Clinica]]></source>
<year>2015</year>
<volume>144</volume>
<page-range>30-4</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
