<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0872-0754</journal-id>
<journal-title><![CDATA[Nascer e Crescer]]></journal-title>
<abbrev-journal-title><![CDATA[Nascer e Crescer]]></abbrev-journal-title>
<issn>0872-0754</issn>
<publisher>
<publisher-name><![CDATA[Centro Hospitalar do Porto]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0872-07542022000100031</article-id>
<article-id pub-id-type="doi">10.25753/birthgrowthmj.v31.i1.20898</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Cross-allergy between penicillins and cephalosporins: a paradigm shift]]></article-title>
<article-title xml:lang="pt"><![CDATA[Reatividade cruzada entre penicilinas e cefalosporinas: mudança de paradigma]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Dias]]></surname>
<given-names><![CDATA[Liliana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pedrosa]]></surname>
<given-names><![CDATA[Cláudia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Hospitalar Vila Nova Gaia/ Espinho Department of Allergy and Clinical Immunology, Unidade I ]]></institution>
<addr-line><![CDATA[Vila Nova de Gaia ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Hospitalar Vila Nova de Gaia/Espinho Department of Pediatrics, Unidade II Immunoallergology and Pediatric Pulmonology Unit]]></institution>
<addr-line><![CDATA[Vila Nova de Gaia ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>03</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>03</month>
<year>2022</year>
</pub-date>
<volume>31</volume>
<numero>1</numero>
<fpage>31</fpage>
<lpage>37</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0872-07542022000100031&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0872-07542022000100031&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0872-07542022000100031&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Allergic reactions to beta-lactam antibiotics are the most common cause of allergic drug reactions. The incorrect diagnosis prevents patients from receiving a highly effective therapy. The potential cross-reactivity between penicillin and cephalosporin has very significant therapeutic implications. Penicillins and cephalosporins share a common beta-lactam ring and side chains. A number of studies indicate that the R1 side chain, rather than the ring itself, is the determining factor for cross-reactivity. Herein is presented a review of the immunologic mechanisms implicated in penicillin and cephalosporin cross-reactivity and a practical approach to the use of cephalosporins in patients allergic to penicillin.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo A alergia aos antibióticos beta-lactâmicos é a causa mais frequente de alergia secundária a fármacos. O diagnóstico incorreto impede os doentes de receber uma opção terapêutica altamente efetiva. A reatividade cruzada entre penicilina e cefalosporina tem importantes implicações terapêuticas. A estrutura das penicilinas e cefalosporinas partilha o anel beta-lactâmico e as cadeias laterais. Vários estudos implicam a cadeia lateral R1 e não o anel beta-lactâmico como fator determinante para a reatividade cruzada. O presente artigo faz uma revisão dos mecanismos imunológicos envolvidos na reatividade cruzada e apresenta uma abordagem prática ao uso de cefalosporinas em doentes alérgicos a penicilina.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[cephalosporin]]></kwd>
<kwd lng="en"><![CDATA[cross-reactivity]]></kwd>
<kwd lng="en"><![CDATA[penicillin]]></kwd>
<kwd lng="en"><![CDATA[side chain]]></kwd>
<kwd lng="pt"><![CDATA[cadeia lateral]]></kwd>
<kwd lng="pt"><![CDATA[cefalosporina]]></kwd>
<kwd lng="pt"><![CDATA[penicilina]]></kwd>
<kwd lng="pt"><![CDATA[reatividade cruzada]]></kwd>
</kwd-group>
</article-meta>
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