<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0872-0754</journal-id>
<journal-title><![CDATA[Nascer e Crescer]]></journal-title>
<abbrev-journal-title><![CDATA[Nascer e Crescer]]></abbrev-journal-title>
<issn>0872-0754</issn>
<publisher>
<publisher-name><![CDATA[Centro Hospitalar do Porto]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0872-07542022000300220</article-id>
<article-id pub-id-type="doi">10.25753/birthgrowthmj.v31.i3.27984</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Pediatric COVID-19 &#9472; What kind of disease is it?]]></article-title>
<article-title xml:lang="pt"><![CDATA[COVID-19 pediátrica - Que tipo de doença é esta?]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Salazar]]></surname>
<given-names><![CDATA[Luís]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Curto]]></surname>
<given-names><![CDATA[Carolina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lima]]></surname>
<given-names><![CDATA[Joana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Correia]]></surname>
<given-names><![CDATA[Cláudia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Teixeira]]></surname>
<given-names><![CDATA[Carla]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernandes]]></surname>
<given-names><![CDATA[Alexandre]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Marques]]></surname>
<given-names><![CDATA[Laura]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Caldas-Afonso]]></surname>
<given-names><![CDATA[Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Hospitalar e Universitário do Porto Centro Materno-Infantil do Norte Department of Pediatrics]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Hospitalar e Universitário do Porto Department of Pediatrics Infectious Diseases and Immunodeficiencies Unit]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>09</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>09</month>
<year>2022</year>
</pub-date>
<volume>31</volume>
<numero>3</numero>
<fpage>220</fpage>
<lpage>225</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0872-07542022000300220&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0872-07542022000300220&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0872-07542022000300220&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background:  The burden of COVID-19 is reported to be less significant in pediatric patients, with lower morbidity and mortality. Our center secured daily telephone follow-up for pediatric COVID-19 outpatients during the isolation period of the pandemic. The aim of this study was to describe COVID-19 manifestations in the pediatric population.  Methods:  This was a retrospective cohort study of pediatric COVID-19 patients conducted between March 2020 and September 2021. Pediatric patients with positive SARS-CoV-2 nucleic acid amplification test performed in Emergency Department, hospitalization, or pre-surgery setting in our center, and patients followed in regular appointments in our center with positive SARS-CoV-2 test performed elsewhere were included. Cases of multisystem inflammatory syndrome in children were excluded. Demographic data, medical history, and data regarding disease course and severity were collected.  Results:  Two hundred and forty-two patients were included, with a median (range) age of 48 (10-144) months. Approximately one third of patients (36.0%) had at least one chronic condition, and 142 had had a prior contact with an infected relative. At diagnosis, the large majority of patients (83.9%) were symptomatic, with fever, cough, rhinorrhea, and nasal congestion as main complaints. A total of 19.8% of patients were initially hospitalized. Among the 194 patients discharged, 22 required reassessment, eight of whom needed hospitalization. Most of these (91.7%) had mild disease or were asymptomatic, while 5.8% fulfilled criteria for moderate disease and 2.5% for severe disease. Two patients required admission to the Intensive Care Unit, one of whom died.  Conclusions:  In this pediatric cohort, COVID-19 presented mostly as a mild disease, with non-specific and multiple symptoms. The close follow-up conducted at our center enabled a better understanding of the disease and minimizing unnecessary emergency visits and hospitalizations, while maintaining adequate patient follow-up.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo  Introdução:  O impacto da COVID-19 tem sido menos significativo em doentes pediátricos, apresentando menor morbilidade e mortalidade. O nosso centro assegurou um acompanhamento telefónico diário para doentes COVID-19 pediátricos não hospitalizados durante o período de isolamento. O objetivo deste estudo foi descrever as manifestações de COVID-19 na população pediátrica.  Métodos:  Este foi um estudo de coorte retrospetivo de doentes COVID-19 pediátricos conduzido entre março de 2020 e setembro de 2021. Foram incluídos doentes pediátricos com teste PCR positivo para SARS-CoV-2 efetuado no nosso centro em contexto de Serviço de Urgência, hospitalização ou pré-cirurgia e doentes seguidos em consulta no nosso centro com teste positivo para SARS-CoV-2 realizado noutra instituição. Foram excluídos casos de síndrome inflamatória multissistémica em crianças. Foram recolhidos dados demográficos, antecedentes clínicos e informação sobre a evolução e gravidade da doença.  Resultados:  Foram incluídos 242 doentes no estudo, com uma mediana de 48 (10-144) meses de idade. Aproximadamente um terço (36.0%) tinha pelo menos uma doença crónica e 142 tinham tido contacto prévio com um familiar infetado. No momento do diagnóstico, a grande maioria (83,9%) dos doentes estava sintomática, sendo os sintomas mais frequentes febre, tosse, rinorreia e obstrução nasal. Um total de 19,8% dos doentes foram inicialmente hospitalizados. Dos 194 doentes que tiveram alta, 22 necessitaram de reobservação e oito destes foram internados. A maioria dos doentes teve doença ligeira ou assintomática (91,7%), com 5,8% a apresentar doença moderada e 2,5% doença grave. Dois doentes necessitaram de admissão na Unidade de Cuidados Intensivos, um dos quais faleceu.  Conclusões:  Nesta coorte pediátrica, a COVID-19 apresentou-se maioritariamente como uma doença ligeira, com sintomas múltiplos e inespecíficos. A monitorização destes doentes permitiu um melhor conhecimento da infeção, minimizar idas desnecessárias ao Serviço de Urgência e hospitalizações e um adequado seguimento dos mesmos.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[homecare]]></kwd>
<kwd lng="en"><![CDATA[pediatric age]]></kwd>
<kwd lng="pt"><![CDATA[COVID-19]]></kwd>
<kwd lng="pt"><![CDATA[hospitalização domiciliária]]></kwd>
<kwd lng="pt"><![CDATA[idade pediátrica]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="">
<collab>World Health Organization</collab>
<source><![CDATA[WHO timeline]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="">
<collab>World o Meter</collab>
<source><![CDATA[Coronavirus in Portugal]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="">
<collab>UNICEF</collab>
<source><![CDATA[UNICEF data hub - COVID-19 and children]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dawood]]></surname>
<given-names><![CDATA[FS]]></given-names>
</name>
<name>
<surname><![CDATA[Porucznik]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Veguilla]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Stanford]]></surname>
<given-names><![CDATA[JB]]></given-names>
</name>
<name>
<surname><![CDATA[Duque]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Rolfes]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Incidence rates, household infection risk, and clinical characteristics of SARS-CoV-2 infection among children and adults in Utah and New York City, New York]]></article-title>
<source><![CDATA[JAMA Pediatr]]></source>
<year>2022</year>
<volume>176</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>59-67</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="">
<collab>World o Meter</collab>
<source><![CDATA[Coronavirus Cases in World]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Leidman]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Duca]]></surname>
<given-names><![CDATA[LM]]></given-names>
</name>
<name>
<surname><![CDATA[Omura]]></surname>
<given-names><![CDATA[JD]]></given-names>
</name>
<name>
<surname><![CDATA[Proia]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Stephens]]></surname>
<given-names><![CDATA[JW]]></given-names>
</name>
<name>
<surname><![CDATA[Sauber-Schatz]]></surname>
<given-names><![CDATA[EK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[COVID-19 Trends Among Persons Aged 0-24 Years - United States, March 1-December 12, 2020]]></article-title>
<source><![CDATA[MMWR Morb Mortal Wkly Rep]]></source>
<year>2021</year>
<volume>70</volume>
<page-range>88-94</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Xu]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Dozier]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[He]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Kirolos]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Lang]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Song]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Theodoratou]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The role of children in the transmission of SARS-CoV2 updated rapid review]]></article-title>
<source><![CDATA[J Glob Health]]></source>
<year>2020</year>
<volume>10</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>021101</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Patel]]></surname>
<given-names><![CDATA[NA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pediatric COVID-19 Systematic review of the literature]]></article-title>
<source><![CDATA[Am J Otolaryngol]]></source>
<year>2020</year>
<volume>41</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>102573</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chang]]></surname>
<given-names><![CDATA[TH]]></given-names>
</name>
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Chang]]></surname>
<given-names><![CDATA[LY]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical characteristics and diagnostic challenges of pediatric COVID-19 A systematic review and meta-analysis]]></article-title>
<source><![CDATA[J Formos Med Assoc]]></source>
<year>2020</year>
<volume>119</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>982-9</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Whitaker]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hospitalization rates and characteristics of children aged &amp;lt;18 years hospitalized with laboratory-confirmed COVID-19 - COVID-NET, 14 States, March 1-July 25, 2020]]></article-title>
<collab>O'Halloran A.Kambhampati A.Chai SJ.Reingold A</collab>
<source><![CDATA[MMWR Morb Mortal Wkly Rep]]></source>
<year>2020</year>
<volume>69</volume>
<numero>32</numero>
<issue>32</issue>
<page-range>1081-8</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stokes]]></surname>
<given-names><![CDATA[EK]]></given-names>
</name>
<name>
<surname><![CDATA[Zambrano]]></surname>
<given-names><![CDATA[LD]]></given-names>
</name>
<name>
<surname><![CDATA[Anderson]]></surname>
<given-names><![CDATA[KN]]></given-names>
</name>
<name>
<surname><![CDATA[Marder]]></surname>
<given-names><![CDATA[EP]]></given-names>
</name>
<name>
<surname><![CDATA[Raz]]></surname>
<given-names><![CDATA[KM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Coronavirus Disease 2019 Case Surveillance - United States, January 22-May 30, 2020]]></article-title>
<collab>El Burai Felix S</collab>
<source><![CDATA[MMWR Morb Mortal Wkly Rep]]></source>
<year>2020</year>
<volume>69</volume>
<numero>24</numero>
<issue>24</issue>
<page-range>759-65</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bellino]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Punzo]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Rota]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Manso]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Urdiales]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
<name>
<surname><![CDATA[Andrianou]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Disease Severity Risk Factors for Pediatric Patients in Italy]]></article-title>
<source><![CDATA[Pediatrics]]></source>
<year>2020</year>
<volume>146</volume>
<numero>4</numero>
<issue>4</issue>
</nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Graff]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Smith]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Silveira]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Jung]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Curran-Hays]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Risk Factors for Severe COVID-19 in Children]]></article-title>
<collab>Jarjour j</collab>
<source><![CDATA[Pediatr Infect Dis J]]></source>
<year>2021</year>
<volume>40</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>e137-45</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
