<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0872-0754</journal-id>
<journal-title><![CDATA[Nascer e Crescer]]></journal-title>
<abbrev-journal-title><![CDATA[Nascer e Crescer]]></abbrev-journal-title>
<issn>0872-0754</issn>
<publisher>
<publisher-name><![CDATA[Centro Hospitalar do Porto]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0872-07542023000200103</article-id>
<article-id pub-id-type="doi">10.25753/birthgrowthmj.v32.i2.26186</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Young-onset acromegaly and gigantism: Causes and clinical features of growth hormone overproduction]]></article-title>
<article-title xml:lang="pt"><![CDATA[Acromegalia e gigantismo em idade pediátrica: Causas e manifestações clínicas do excesso de produção de hormona do crescimento]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castro]]></surname>
<given-names><![CDATA[Raquel Vaz de]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Faustino]]></surname>
<given-names><![CDATA[Joana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[Florbela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sampaio]]></surname>
<given-names><![CDATA[Lurdes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Hospitalar Universitário Lisboa Norte Hospital de Santa Maria Department of Endocrinology, Diabetes and Metabolism]]></institution>
<addr-line><![CDATA[Lisboa ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Hospitalar Universitário de Lisboa Central Hospital Dona Estefânia Department of Pediatrics]]></institution>
<addr-line><![CDATA[Lisboa ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Centro Hospitalar Universitário Lisboa Norte Department of Pediatrics Hospital de Santa Maria Pediatric Endocrinology Unit]]></institution>
<addr-line><![CDATA[Lisboa ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2023</year>
</pub-date>
<volume>32</volume>
<numero>2</numero>
<fpage>103</fpage>
<lpage>107</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0872-07542023000200103&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0872-07542023000200103&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0872-07542023000200103&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Depending on the age of onset, the excessive release of growth hormone (GH) &#8722; most commonly by a pituitary tumor &#8722; and subsequently of insulin-like growth factor 1 (IGF1) can cause acromegaly and gigantism. The purpose of this study was to describe the clinical manifestations and main known causes of GH overproduction. GH-releasing hormone and IGF1 can result in a series of physical traits and comorbidities due to hormonal imbalance and somatic overgrowth. To date, several syndromes and genetic mutations have been linked to the etiology of acromegaly.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo A acromegalia e o gigantismo são doenças raras causadas pela secreção excessiva de hormona do crescimento &#8722; mais frequentemente causada por um tumores hipofisário &#8722; e subsequente produção excessiva de fator de crescimento semelhante à insulina 1. O objetivo deste estudo foi rever as manifestações clínicas e principais causas conhecidas de produção excessiva de hormona de crescimento. A ação da hormona de crescimento condiciona sinais e sintomas dependentes, entre outros, da fase de crescimento do doente, isto é, da patência ou encerramento das epífises ósseas na altura do aparecimento da doença. Estão atualmente identificadas várias síndromes e mutações genéticas associadas à etiopatogenia da acromegalia.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[acromegaly]]></kwd>
<kwd lng="en"><![CDATA[gigantism]]></kwd>
<kwd lng="en"><![CDATA[cause]]></kwd>
<kwd lng="en"><![CDATA[clinical feature]]></kwd>
<kwd lng="pt"><![CDATA[acromegalia]]></kwd>
<kwd lng="pt"><![CDATA[gigantismo]]></kwd>
<kwd lng="pt"><![CDATA[causa]]></kwd>
<kwd lng="pt"><![CDATA[manifestação clínica]]></kwd>
</kwd-group>
</article-meta>
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