I.H.I. Habib1,*, S.A. Weshahy2, S. Toubar3 and M.M.A. El-Alamin3
1Analytical Chem. Lab., Applied Organic Chem. Dept., National Research Centre, Dokki, Cairo, Egypt
2Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt
3Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, Egypt
Received 14th November 2007; accepted 29th January 2008
Abstract
]]> Cathodic stripping voltammetric determination of losartan using hanging mercury drop electrode HMDE was described. The method was based on adsorptive accumulation of the species at HMDE and at pH 7, followed by alternating current AC sweep. The behavior of adsorptive stripping response was studied under various experimental conditions, e.g. type of supporting electrolyte, pH, accumulation time, scan rate and mode of sweep (direct current DC, differential pulse DP, square wave SW and AC). In Britton-Robinson buffer solution, pH 7, a quasi-reversible reaction took place. The reduction response was more sensitive than the oxidation one and it was linear over the concentration range of 0.16-1.2 mg/mL. The determination of the cited compound in oral dosages was achieved using the standard addition method. The average of determinations obtained by square wave adsorptive voltammetric method with its standard deviation was 100.1±3%.
Keywords: losartan, adsorptive stripping voltammetry, HMDE, stability.
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* Corresponding author. E-mail address: ihihabib@yahoo.com
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