<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0872-671X</journal-id>
<journal-title><![CDATA[Medicina Interna]]></journal-title>
<abbrev-journal-title><![CDATA[Medicina Interna]]></abbrev-journal-title>
<issn>0872-671X</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0872-671X2021000100052</article-id>
<article-id pub-id-type="doi">10.24950/r/190/20/1/2021</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Evidência dos Modificadores do Sistema Renina-Angiotensina na Prevenção da Enxaqueca Episódica]]></article-title>
<article-title xml:lang="en"><![CDATA[Evidence of Renin-Angiotensin System Modifiers in the Prevention of Episodic Migraine]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alves]]></surname>
<given-names><![CDATA[Sara Carneiro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[José Augusto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodrigues]]></surname>
<given-names><![CDATA[Catarina Ramos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moura]]></surname>
<given-names><![CDATA[Adriana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Agrupamento de Centros de Saúde Póvoa de Varzim/Vila do Conde Unidade de Saúde Familiar Corino de Andrade ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Agrupamento de Centros de Saúde Póvoa de Varzim/Vila do Conde Unidade de Saúde Familiar Navegantes ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Agrupamento de Centros de Saúde Póvoa de Varzim/Vila do Conde Unidade de Saúde Familiar Eça de Queirós ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Agrupamento de Centros de Saúde Póvoa de Varzim/Vila do Conde Unidade de Saúde Familiar Casa dos Pescadores ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2021</year>
</pub-date>
<volume>28</volume>
<numero>1</numero>
<fpage>52</fpage>
<lpage>58</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0872-671X2021000100052&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0872-671X2021000100052&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0872-671X2021000100052&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo: Introdução:A enxaqueca é uma doença frequente e incapacitante. Modelos experimentais sugerem uma relação entre o sistema renina-angiotensina e o desenvolvimento de enxaqueca. Este artigo tem como objetivo rever a evidência dos inibidores deste sistema na redução da frequência dos episódios de enxaqueca.   Métodos:  Foi efetuada a pesquisa de normas de orientação clínica (NOC), de revisões sistemáticas (RS) e meta-análises (MA), bem como de ensaios clínicos aleatorizados (ECA). O nível de evidência e forças de recomendação foram atribuídos recorrendo à escala Strength of Recommendation Taxonomy (SORT).   Resultados:  Foram identificados 63 artigos, tendo sido selecionados oito: quatro NOC, duas RS/MA e duas RS.  Discussão/Conclusão: O tratamento preventivo da enxaqueca episódica pode ser efetuado com candesartan 16 mg/dia (FR B), embora ainda não seja recomendado como fármaco de primeira linha. O lisinopril também mostrou potencial na prevenção da enxaqueca episódica (FR B).]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Introduction:Migraine is a common and disabling disease. Experimental models suggest an association between renin-angiotensin system and migraine development. This paper aims to review the evidence of angiotensin inhibitors in reducing migraine episodes.   Methods:  We searched for guidelines, systematic reviews, meta-analysis and randomized controlled trials. Level of evidence and strength of recommendation (SOR) attribution were based on Strength of Recommendation Taxonomy (SORT).   Results:  We identified 63 articles, from which we selected eight: four guidelines, two meta-analysis and two systematic review.   Discussion/Conclusion:  Candesartan 16 mg/day may be used as a preventive treatment of episodic migraine (SOR B), in spite of not being recommended as the first line of treatment. Lisinopril also showed some potential. (SOR B)]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Inibidores da Enzima Conversora de Angiotensina]]></kwd>
<kwd lng="pt"><![CDATA[Perturbações de Enxaqueca/prevenção e controlo]]></kwd>
<kwd lng="en"><![CDATA[Angiotensin-Converting Enzyme Inhibitors]]></kwd>
<kwd lng="en"><![CDATA[Migraine Disorders/prevention &amp; control]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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