<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0872-671X</journal-id>
<journal-title><![CDATA[Medicina Interna]]></journal-title>
<abbrev-journal-title><![CDATA[Medicina Interna]]></abbrev-journal-title>
<issn>0872-671X</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0872-671X2021000200023</article-id>
<article-id pub-id-type="doi">10.24950/o/30/21/2/2021</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Demographic Characterization, Clinical Course and Risk Factors for Mortality of Adult Inpatients with COVID-19: A Single-Centre Experience from the First Outbreak in Portugal]]></article-title>
<article-title xml:lang="pt"><![CDATA[Caracterizacao Demografica, Curso Clinico e Fatores de Risco para Mortalidade em Doentes Hospitalizados com COVID-19: Experiencia de um Hospital Terciario Portugues na Primeira Vaga da Pandemia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Meireles]]></surname>
<given-names><![CDATA[Pedro Antunes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gaspar]]></surname>
<given-names><![CDATA[Pedro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Parreira]]></surname>
<given-names><![CDATA[Inês]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Abrantes]]></surname>
<given-names><![CDATA[Ana Mafalda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[Virgílio Dias]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bessa]]></surname>
<given-names><![CDATA[Filipe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lacerda]]></surname>
<given-names><![CDATA[António Pais de]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mota]]></surname>
<given-names><![CDATA[Catarina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A5"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Hospitalar Universitário Lisboa Norte Hospital de Santa Maria Serviço de Medicina 2]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Português de Oncologia de Lisboa Francisco Gentil Serviço de Oncologia Médica ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidade de Lisboa Faculdade de Medicina ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Centro Hospitalar Universitário Lisboa Norte Hospital de Santa Maria Serviço de Medicina Intensiva]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidade de Lisboa Instituto de Medicina Molecular, João Lobo Antunes ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>06</month>
<year>2021</year>
</pub-date>
<volume>28</volume>
<numero>2</numero>
<fpage>23</fpage>
<lpage>32</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0872-671X2021000200023&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0872-671X2021000200023&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0872-671X2021000200023&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract   Introduction:  Clinical characteristics of Portuguese inpatients with coronavirus disease 2019 (COVID-19) are scarce. We aim to describe the demographic characteristics, clinical course and outcomes of hospitalized patients with COVID-19 and to analyze risk factors for in-hospital mortality.  Material and Methods:  Ambispective cohort study of adult COVID-19 patients admitted to a Portuguese tertiary hospital between March and August 2020. Asymptomatic, pregnant and all patients admitted due to social reasons were excluded.  Results:  Of the 432 admitted patients, 279 individuals were included. The median age was 69 years and 57% were male. The most common comorbidities were high blood pressure (66.3%), dyslipidemia (33.3%), diabetes (27.1%) and cardiovascular disease (CVD) (26.5%). The most common symptoms included fever (74.4%), cough (67.0%) and dyspnea (59.9%). Ferritin, C-reactive protein and D-dimer levels were elevated in 86.3%, 74.8% and 73.9% of patients, respectively. Mortality rate was 17.3%. 32.3% of the patients developed acute respiratory distress syndrome, 31.9% were admitted to intensive care unit and 20.8% were ventilated. In multivariable analysis, age (OR 1.04, 95% CI 1.01-1.09, p=0.023), CVD (OR 2.68, 95% CI 1.21-5.93, p=0.015) and lymphocyte count &lt;0.5x109/L (OR 6.61, 95% CI 2.23-19.62, p=0.001) were risk factors for in-hospital mortality.  Discussion:  Our demographics, clinical and severity outcomes are in-line with international reports. Compared to other European countries, our less expressive in-hospital mortality rate might reflect a modestly controlled first outbreak in our country.  Conclusion: This single-center study provides data on the clinical characteristics and outcomes of hospitalized patients with COVID-19 in Portugal.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo   Introdução:  As informacoes relativas as caracteristicas clinicas e demograficas dos doentes portugueses hospitalizados com COVID-19 sao limitadas.  Material e Métodos:  Estudo ambispetivo dos doentes internados com COVID-19 num hospital terciario portugues entre marco e agosto de 2020. Foram excluidos os doentes assintomaticos, mulheres gravidas e os internados por causas sociais.  Resultados:  Dos 432 doentes internados, foram incluidos 279. A idade mediana foi de 69 anos, 57% do sexo masculino. As comorbilidades mais frequentes foram a hipertensao arterial (66,3%), dislipidemia (33,3%), diabetes (27,1%) e doenca cardiovascular (DCV) (26,5%). A sintomatologia mais frequente a admissao foi febre (74,4%), tosse (67,0%) e dispneia (59,9%). As alteracoes laboratoriais mais frequentes foram niveis elevados de ferritina (86,3%), proteina c-reativa (74,8%) e d-dimeros (73,9%). A taxa de mortalidade foi 17,3%, 32,3% dos doentes desenvolveram sindrome de dificuldade respiratoria aguda, 31,9% foram admitidos numa unidade de cuidados intensivos e 20,8% foram ventilados mecanicamente. Na analise multivariavel, a idade (OR 1,04, 95% CI 1,01-1,09, p=0,023), DCV (OR 2,68, 95% CI 1,21-5,93, p=0,015) e linfopenia &lt;0,5x109/L (OR 6,61, 95% CI 2,23-19,62, p=0,001) identificaram-se como os principais fatores de risco de mortalidade intra-hospitalar.  Discussão:  Os nossos dados demograficos e desfechos clinicos equiparam-se aos estudos publicados ate a data. Em comparacao com os estudos em populacoes europeias, relatamos uma menor taxa de mortalidade intra-hospitalar, o que podera refletir um melhor controlo da primeira vaga da pandemia no nosso pais.  Conclusão:  Este estudo fornece informacao acerca das caracteristicas clinicas dos doentes com COVID-19 hospitalizados em Portugal.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[COVID-19]]></kwd>
<kwd lng="pt"><![CDATA[Demografia]]></kwd>
<kwd lng="pt"><![CDATA[Factores de Risco]]></kwd>
<kwd lng="pt"><![CDATA[Mortalidade]]></kwd>
<kwd lng="pt"><![CDATA[Portugal]]></kwd>
<kwd lng="pt"><![CDATA[SARS-CoV-2.]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[Demography]]></kwd>
<kwd lng="en"><![CDATA[Mortality]]></kwd>
<kwd lng="en"><![CDATA[Portugal]]></kwd>
<kwd lng="en"><![CDATA[Risk Factors]]></kwd>
<kwd lng="en"><![CDATA[SARS-CoV-2.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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