<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0872-671X</journal-id>
<journal-title><![CDATA[Medicina Interna]]></journal-title>
<abbrev-journal-title><![CDATA[Medicina Interna]]></abbrev-journal-title>
<issn>0872-671X</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0872-671X2022000100002</article-id>
<article-id pub-id-type="doi">10.24950/rspmi.2022.01.192</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Indicações Terapêuticas e Profiláticas de Uso de Inibidores da Bomba de Protões e Prescrição Inadequada]]></article-title>
<article-title xml:lang="en"><![CDATA[Therapeutic and Prophylactic Indications for Use of Proton Pump Inhibitors and Inappropriate Prescribing]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jorge]]></surname>
<given-names><![CDATA[Clara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tuna]]></surname>
<given-names><![CDATA[Célia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carlos]]></surname>
<given-names><![CDATA[Pedro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[Sara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gonçalves]]></surname>
<given-names><![CDATA[Renato]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Louro]]></surname>
<given-names><![CDATA[Marlene]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Hospitalar Universitário Cova da Beira Serviço de Medicina Interna ]]></institution>
<addr-line><![CDATA[Covilhã ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>30</day>
<month>03</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>30</day>
<month>03</month>
<year>2022</year>
</pub-date>
<volume>29</volume>
<numero>1</numero>
<fpage>2</fpage>
<lpage>6</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0872-671X2022000100002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0872-671X2022000100002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0872-671X2022000100002&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo  Introdução:  Os inibidores da bomba de protões representam uma das classes medicamentosas mais prescritas, e são muitas vezes mantidos sem reavaliação da necessidade de tratamento. Os objetivos deste estudo foram identificar as indicações terapêuticas e profiláticas de uso, analisar as caraterísticas demográficas dos doentes e a frequência relativa do uso inadequado.  Material e Métodos:  Estudo retrospetivo, observacional do tipo transversal, onde foram consultados os processos clínicos dos doentes internados no Serviço de Medicina Interna de um Hospital distrital universitário no período de Junho a Outubro de 2020, e cuja medicação habitual incluía um inibidor da bomba de protões.  Resultados:  76,4% dos doentes (n = 233) encontravam-se sob inibidores da bomba de protões sem indicação.  Conclusão:  O facto de não estarem sujeitos a receita médica, contribuiu para o consumo excessivo e crescente, sem parecer médico. No entanto, é fundamental avaliar as indicações de tratamento e uso inapropriado, uma vez que vários estudos expuseram potenciais reações adversas associadas à exposição prolongada.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction:  Proton pump inhibitors represent one of the most prescribed drug classes, often maintained without reevaluation of the need for treatment. The goals for this study were to identify the therapeutic and prophylactic indications of use, analyze the demographic characteristics of patients and the relative frequency of inappropriate use.  Material and Methods:  Retrospective, observational, cross-sectional study, which consulted the clinical files of patients admitted in Internal Medicine Services of a District Hospital from June to October 2020, and whose usual medication included a proton pump inhibitor.  Results:  76.4% of patients (n = 233) were under proton pump inhibitors with no indication.  Conclusion:  The fact that they are not subjected to a prescription, contributed to their excessive and growing consumption without medical opinion. However, it is essential to evaluate the indications for treatment and inappropriate use as several studies have exposed potential adverse reactions associated with prolonged exposure.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Inibidores da Bomba de Protões/uso terapêutico]]></kwd>
<kwd lng="pt"><![CDATA[Prescrição Inadequada.]]></kwd>
<kwd lng="en"><![CDATA[Inappropriate Prescribing]]></kwd>
<kwd lng="en"><![CDATA[Proton Pump Inhibitors/therapeutic use.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[de la Coba]]></surname>
<given-names><![CDATA[Ortiz C]]></given-names>
</name>
<name>
<surname><![CDATA[Argüelles]]></surname>
<given-names><![CDATA[Arias F]]></given-names>
</name>
<name>
<surname><![CDATA[Martín]]></surname>
<given-names><![CDATA[de Argila de Prados C]]></given-names>
</name>
<name>
<surname><![CDATA[Júdez]]></surname>
<given-names><![CDATA[Gutiérrez J]]></given-names>
</name>
<name>
<surname><![CDATA[Linares]]></surname>
<given-names><![CDATA[Rodríguez A]]></given-names>
</name>
<name>
<surname><![CDATA[Ortega]]></surname>
<given-names><![CDATA[Alonso A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Proton-pump inhi-bitors adverse effects a review of the evidence and position statement by the Sociedad Española de Patología Digestiva]]></article-title>
<source><![CDATA[Rev Esp Enferm Dig]]></source>
<year>2016</year>
<volume>108</volume>
<page-range>207-24</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brayfield]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Martindale: The Complete Drug Reference]]></source>
<year>2014</year>
<edition>38</edition>
<publisher-loc><![CDATA[London ]]></publisher-loc>
<publisher-name><![CDATA[Pharmaceutical Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nehra]]></surname>
<given-names><![CDATA[AK]]></given-names>
</name>
<name>
<surname><![CDATA[Alexander]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Loftus]]></surname>
<given-names><![CDATA[CG]]></given-names>
</name>
<name>
<surname><![CDATA[Nehra]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Proton pump inhibitors re-view of emerging concerns]]></article-title>
<source><![CDATA[Mayo Clin Proc]]></source>
<year>2018</year>
<volume>93</volume>
<page-range>240-6</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lehault]]></surname>
<given-names><![CDATA[WB]]></given-names>
</name>
<name>
<surname><![CDATA[Hughes]]></surname>
<given-names><![CDATA[DM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Review of the long-term effects of proton pump inhibitors]]></article-title>
<source><![CDATA[Federal Practitioner]]></source>
<year>2017</year>
<volume>34</volume>
<page-range>19-23</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="">
<collab>WeMeRec Bulletin</collab>
<article-title xml:lang=""><![CDATA[Proton pump inhibitors]]></article-title>
<source><![CDATA[]]></source>
<year>2015</year>
</nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yadlapati]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Kahrilas]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[When is proton pump inhibitor use appropriate BioMed]]></article-title>
<source><![CDATA[Central]]></source>
<year>2017</year>
<volume>15</volume>
<page-range>36</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="book">
<collab>Comissão de Farmácia e Terapêutica da Administração Regional de Saude de Lisboa e Vale do Tejo</collab>
<source><![CDATA[Boletim terapêutico nº 1/ Janeiro 2016]]></source>
<year>2016</year>
<publisher-loc><![CDATA[Lisboa ]]></publisher-loc>
<publisher-name><![CDATA[ARSLVT]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vilela]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Magalhães]]></surname>
<given-names><![CDATA[AL]]></given-names>
</name>
<name>
<surname><![CDATA[Neto]]></surname>
<given-names><![CDATA[GA]]></given-names>
</name>
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[PI]]></given-names>
</name>
<name>
<surname><![CDATA[Morais]]></surname>
<given-names><![CDATA[FG]]></given-names>
</name>
<name>
<surname><![CDATA[Magalhães]]></surname>
<given-names><![CDATA[AC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[O uso de AINES, incluindo aspirina, na prevenção primária da toxicidade gastroduodenal]]></article-title>
<source><![CDATA[Brazil J Surg Clin Res]]></source>
<year>2021</year>
<volume>34</volume>
<page-range>42-7</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lanza]]></surname>
<given-names><![CDATA[FL]]></given-names>
</name>
<name>
<surname><![CDATA[Chan]]></surname>
<given-names><![CDATA[FK]]></given-names>
</name>
<name>
<surname><![CDATA[Quigley]]></surname>
<given-names><![CDATA[EM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Practice Parameters Committee of the American College of Gastroenterology Guidelines for prevention of NSAID related ulcer complications]]></article-title>
<source><![CDATA[Am J Gastroenterol]]></source>
<year>2009</year>
<volume>104</volume>
<page-range>728</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Zhu]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Proton pump inhibitor utilisation and potentially inappropriate prescribing analysis insights from a single-centred retrospective study]]></article-title>
<source><![CDATA[BMJ Open]]></source>
<year>2020</year>
<volume>10</volume>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Giannini]]></surname>
<given-names><![CDATA[EG]]></given-names>
</name>
<name>
<surname><![CDATA[Crespi]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Djahandideh]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Demarzo]]></surname>
<given-names><![CDATA[MG]]></given-names>
</name>
<name>
<surname><![CDATA[Moscatelli]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bodini]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Appropriateness of proton pump inhibitors treatment in clinical practice prospective evaluation in outpatients and perspective assess-ment of drug optimisation]]></article-title>
<source><![CDATA[Dig Liver Dis]]></source>
<year>2020</year>
<volume>52</volume>
<page-range>862-8</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Thomas]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Culley]]></surname>
<given-names><![CDATA[EJ]]></given-names>
</name>
<name>
<surname><![CDATA[Gladowski]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Longitudinal analysis of the costs associated with inpatient initiation and subsequent outpatient continuation of proton pump inhibitor therapy for stress ulcer prophylaxis in a large managed care organization]]></article-title>
<collab>off V.Fong J.Marche SM</collab>
<source><![CDATA[J Manag Care Pharm]]></source>
<year>2010</year>
<volume>16</volume>
<page-range>122-9</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schnoll-Sussman]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Niec]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Katz]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Proton Pump Inhibitors The Good, Bad, and Ugly]]></article-title>
<source><![CDATA[Gastrointest Endosc Clin N Am]]></source>
<year>2020</year>
<volume>30</volume>
<page-range>239251</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kanno]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Moayyedi]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Proton Pump Inhibitors in the Elderly, Balancing Risk and Benefit: an Age-Old Problem]]></article-title>
<source><![CDATA[Curr Gastroenterol Rep]]></source>
<year>2019</year>
<volume>21</volume>
<page-range>65</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Halfdanarson]]></surname>
<given-names><![CDATA[OO]]></given-names>
</name>
<name>
<surname><![CDATA[Pottegard]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bjornsson]]></surname>
<given-names><![CDATA[ES]]></given-names>
</name>
<name>
<surname><![CDATA[Lund]]></surname>
<given-names><![CDATA[SH]]></given-names>
</name>
<name>
<surname><![CDATA[Ogmundsdottir]]></surname>
<given-names><![CDATA[MH]]></given-names>
</name>
<name>
<surname><![CDATA[Steingrímsson]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Proton-pump inhibitors among adults a natio-nwide drug-utlization study]]></article-title>
<source><![CDATA[Therap Adv Gastroenterol]]></source>
<year>2018</year>
<volume>11</volume>
<page-range>1-11</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Farrell]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Pottie]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Thompson]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Boghossian]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Pizzola]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Rashid]]></surname>
<given-names><![CDATA[FJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Deprescribing proton pump inhibitors evideice-based clinical practice guideline]]></article-title>
<source><![CDATA[Can Fam Physician]]></source>
<year>2017</year>
<volume>63</volume>
<page-range>354-64</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reimer]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Sondergaard]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Hilsted]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Bytzer]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Proton-pump inhibitor the-rapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy]]></article-title>
<source><![CDATA[Gastroenterology]]></source>
<year>2009</year>
<volume>137</volume>
<page-range>80-7</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kahrilas]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Patient education: Gastroesophageal reflux disease in adults (Beyond the Basics)]]></article-title>
<source><![CDATA[]]></source>
<year></year>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
